trans-4-(formylamino)-4-methylcyclohexyl benzoate

Base Information

• Chemical Name: trans-4-(formylamino)-4-methylcyclohexyl benzoate
• CAS No.: 1443999-14-1
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321
• Mol file: 1443999-14-1.mol

Synonyms:

Chemical Property of trans-4-(formylamino)-4-methylcyclohexyl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-4-(formylamino)-4-methylcyclohexyl benzoate

There total 4 articles about trans-4-(formylamino)-4-methylcyclohexyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + cis-4-hydroxy-4-methylcyclohexyl benzoate (85977-98-6) → cis-4-(formylamino)-4-methylcyclohexyl benzoate (1443999-13-0) + trans-4-(formylamino)-4-methylcyclohexyl benzoate (1443999-14-1)

Guidance literature:

With methanesulfonic acid; trifluoroacetic acid; at 90 ℃; for 8h; Overall yield = 17 %;

DOI:10.1055/s-0032-1318477

Reference yield:

1-methyl-1,4-cyclohexanediol (89794-52-5) → cis-4-(formylamino)-4-methylcyclohexyl benzoate (1443999-13-0) + trans-4-(formylamino)-4-methylcyclohexyl benzoate (1443999-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 °C

2: methanesulfonic acid; trifluoroacetic acid / 8 h / 90 °C

With pyridine; methanesulfonic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-0032-1318477

Reference yield:

benzoyl chloride (98-88-4) → cis-4-(formylamino)-4-methylcyclohexyl benzoate (1443999-13-0) + trans-4-(formylamino)-4-methylcyclohexyl benzoate (1443999-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 °C

2: methanesulfonic acid; trifluoroacetic acid / 8 h / 90 °C

With pyridine; methanesulfonic acid; trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-0032-1318477

upstream raw materials:

formamide

cis-4-hydroxy-4-methylcyclohexyl benzoate

trans-4-hydroxy-4-methylcyclohexyl benzoate

1-methyl-1,4-cyclohexanediol

Refernces