(1R,2S,4aR,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

Base Information

• Chemical Name: (1R,2S,4aR,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester
• CAS No.: 132048-22-7
• Molecular Formula: C₂₈H₄₄O₅Si
• Molecular Weight: 488.74

Synonyms:

Chemical Property of (1R,2S,4aR,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,4aR,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester

There total 13 articles about (1R,2S,4aR,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl (2E,8Z,10E)-14-(benzyloxy)-7-(methoxymethoxy)-2-methyl-9-(trimethylsilyl)tetradeca-2,8,10-trienoate (97752-14-2) → methyl 6β-<3-(benzyloxy)prop-1-yl>-1α-(methoxymethoxy)-5α-methyl-8-(trimethylsilyl)-1,2,3,4,4aβ.5.6.7aα-octahydroanphthalene-5β-carboxylate (132048-22-7,132048-23-8,132048-24-9)

Guidance literature:

at 180 ℃; for 24h;

DOI:10.1021/jo00218a040

Reference yield: 67.0%

methyl (2E,8Z,10E)-14-(benzyloxy)-7-(methoxymethoxy)-2-methyl-9-(trimethylsilyl)tetradeca-2,8,10-trienoate (97752-14-2) → (1R,2R,4aS,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester (132048-22-7,132048-23-8,132048-24-9) + methyl 6β-<3-(benzyloxy)prop-1-yl>-1α-(methoxymethoxy)-5α-methyl-8-(trimethylsilyl)-1,2,3,4,4aβ.5.6.7aα-octahydroanphthalene-5β-carboxylate (132048-22-7,132048-23-8,132048-24-9) + (1R,2S,4aR,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester (132048-22-7,132048-23-8,132048-24-9)

Guidance literature:

2,6-di-tert-butyl-4-methyl-phenol; In toluene; at 180 ℃; for 16h; Yields of byproduct given;

DOI:10.1021/jo00003a049

Reference yield: 67.0%

methyl (2E,8Z,10E)-14-(benzyloxy)-7-(methoxymethoxy)-2-methyl-9-(trimethylsilyl)tetradeca-2,8,10-trienoate (97752-14-2) → (1R,2R,4aS,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester (132048-22-7,132048-23-8,132048-24-9) + methyl 6β-<3-(benzyloxy)prop-1-yl>-1α-(methoxymethoxy)-5α-methyl-8-(trimethylsilyl)-1,2,3,4,4aβ.5.6.7aα-octahydroanphthalene-5β-carboxylate (132048-22-7,132048-23-8,132048-24-9) + (1R,2S,4aR,5R,8aR)-2-(3-Benzyloxy-propyl)-5-methoxymethoxy-1-methyl-4-trimethylsilanyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester (132048-22-7,132048-23-8,132048-24-9)

Guidance literature:

2,6-di-tert-butyl-4-methyl-phenol; In toluene; at 180 ℃; for 16h; Yields of byproduct given;

DOI:10.1021/jo00003a049

upstream raw materials:

methyl (2E,8Z,10E)-14-(benzyloxy)-7-(methoxymethoxy)-2-methyl-9-(trimethylsilyl)tetradeca-2,8,10-trienoate

3-(tetrahydropyran-2-yloxy)-1-trimethylsilylprop-1-yne

Trimethyl-[(E)-3-(tetrahydro-pyran-2-yloxy)-propenyl]-silane

(2Z,4E)-8-Benzyloxy-3-trimethylsilanyl-octa-2,4-dienal

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