(R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester
CAS No.:441003-84-5
Molecular Formula:C₃₃H₄₇N₃O₅
Molecular Weight:565.753
Hs Code.:

(R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

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Chemical Property of (R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

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Technology Process of (R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

There total 11 articles about (R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4629-80-5
1,3-dimethyl-4-piperidinone

: 441003-84-5
(R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: tetrahydrofuran

2.1: ethyl acetate

2.2: (+)-diethyl ditoluyltartrate

3.1: decahydronaphthalene / Heating

4.1: n-BuLi

5.1: phenyl chloroformate

6.1: HBr; AcOH

7.1: BOP; Et₃N / tetrahydrofuran

8.1: BH₃*SMe₂ / tetrahydrofuran

9.1: TFA / CH₂Cl₂

10.1: BOP; Et₃N / tetrahydrofuran

With n-butyllithium; dimethylsulfide borane complex; hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; phenyl chloroformate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; ethyl acetate; decalin;
DOI:10.1021/jm030094y

Reference yield:

: 145678-87-1
(-)-3(S),4(S)-dimethyl-4-(3-hydroxyphenyl)piperidine

: 441003-84-5
(R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: BOP; Et₃N / tetrahydrofuran

2: BH₃*SMe₂ / tetrahydrofuran

3: TFA / CH₂Cl₂

4: BOP; Et₃N / tetrahydrofuran

With dimethylsulfide borane complex; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030094y

Reference yield:

: 149541-62-8
Carbonic acid ethyl ester (3R,4S)-4-(3-isopropoxy-phenyl)-1,3-dimethyl-piperidin-4-yl ester

: 441003-84-5
(R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: decahydronaphthalene / Heating

2: n-BuLi

3: phenyl chloroformate

4: HBr; AcOH

5: BOP; Et₃N / tetrahydrofuran

6: BH₃*SMe₂ / tetrahydrofuran

7: TFA / CH₂Cl₂

8: BOP; Et₃N / tetrahydrofuran

With n-butyllithium; dimethylsulfide borane complex; hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; phenyl chloroformate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; decalin;
DOI:10.1021/jm030094y