145678-87-1

Basic information

• Product Name: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE
• Synonyms: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE;(+)-(3s,4s)-3,4-diMethyl-4-(3-hydroxyphenyl)piperidine;(-)-3-[(3S,4S)-3,4-Dimethylpiperidin-4-yl]phenol
• CAS NO: 145678-87-1
• Molecular Formula: C₁₃H₁₉NO
• Molecular Weight: 205.3
• Mol File: 145678-87-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 335.464 °C at 760 mmHg
• Flash Point: 115.716 °C
• Appearance: /
• Density: 1.009 g/cm³
• CAS DataBase Reference: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE(145678-87-1)
• EPA Substance Registry System: (+)-(3R,4S)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE(145678-87-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 145678-87-1(Hazardous Substances Data)

Usage

Uses

(-)-(3S,4S)-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine is a key intermediate used in the preparation of the opioid drug Alvimopan.

Upstream product

• 444904-02-3 (S)-1,2,3,6-tetrahydro-1,3-dimethyl-4-[3-(1-methylethoxy)phenyl]pyridine 
• 223424-24-6 (3S,4S)-4-(3-Isopropoxy-phenyl)-1,3,4-trimethyl-piperidine 
• 149541-62-8 Carbonic acid ethyl ester (3R,4S)-4-(3-isopropoxy-phenyl)-1,3-dimethyl-piperidin-4-yl ester 
• 149541-62-8 cis-(-)-carbonic acid ethyl 1,3-dimethyl-4-[3-(l-methylethoxy)phenyl]-4-piperidinyl ester 
• 131738-73-3 3-(isopropyloxy)phenylbromide 
• 149541-62-8 C₁₉H₂₉NO₄ 
• 145340-44-9 1,3-dimethyl-4-[3-(propan-2-yloxy)phenyl]-4-piperidinol 
• 4629-80-5 1,3-dimethyl-4-piperidinone 

Downstream Products

• 441003-83-4 3-[1-(2S-amino-3-methylbutyl)-3S,4S-dimethyl-4-piperidinyl]phenol 
• 361444-66-8 (3R)-7-hydroxy-N-((1S)-1-{[(3S,4S)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide 
• 441003-84-5 (R)-7-Hydroxy-3-{(S)-1-[(3S,4S)-4-(3-hydroxy-phenyl)-3,4-dimethyl-piperidin-1-ylmethyl]-2-methyl-propylcarbamoyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 156130-44-8 2‐((S)‐2‐benzyl‐3‐((3S,4S)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid 
• 156130-44-8 2‐((R)‐2‐benzyl‐3‐((3S,4S)‐4‐(3‐hydroxyphenyl)‐3,4‐dimethylpiperidin‐1‐yl)propanamido)acetic acid 
• 120938-72-9 LY 255265 
• 120938-72-9 LY 255609 

Relevant articles and documents

Synthesis and characterization of all possible diastereoisomers of alvimopan

Isolation of all possible diastereomers of alvimopan 1 was found to be challenging. In order to perform cut off studies during analytical method development, it was mandatory to synthesize and characterize all the diastereomeric impurities. Here in, our efforts toward the synthesis and isolation of alvimopan (1) diastereomers are discussed.

1,3,4-Trisubstituted-4-arylpiperidines and their preparation

Novel 1,3,4-trisubstituted-4-arylpiperidines are prepared by alkylating a 2,3-disubstituted-3-arylpyrroline to afford a 1,2,3-trisubstituted-3-aryl-1-pyrrolinium salt, reacting the salt with diazomethane to provide a 1,2,3-trisubstituted-3-aryl-1,2-methyl