(R)-6-hydroxyheptanoic acid

Base Information

• Chemical Name: (R)-6-hydroxyheptanoic acid
• CAS No.: 126372-25-6
• Molecular Formula: C₇H₁₄O₃
• Molecular Weight: 146.186
• Mol file: 126372-25-6.mol

Synonyms:

Chemical Property of (R)-6-hydroxyheptanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-6-hydroxyheptanoic acid

There total 8 articles about (R)-6-hydroxyheptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-6-cyano-2-hexanol → (R)-6-hydroxyheptanoic acid (21961-03-5,50516-06-8,126372-25-6)

Guidance literature:

With water; sodium hydroxide; In methanol; at 60 ℃; for 11h; Reflux;

DOI:10.1021/ol302970c

Reference yield:

C9H16O4 → (R)-6-hydroxyheptanoic acid (21961-03-5,50516-06-8,126372-25-6)

Guidance literature:

With sodium methylate; In methanol; at 0 - 20 ℃; for 4h;

DOI:10.1039/d0ob00652a

Reference yield:

(R)-5-acetoxy-1-chlorohexane (154885-34-4) → (R)-6-hydroxyheptanoic acid (21961-03-5,50516-06-8,126372-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; methanol / water / 6 h / 20 °C

2: tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide; ethyl acetate / 18 h / 50 °C / Inert atmosphere

3: water; sodium hydroxide / methanol / 11 h / 60 °C / Reflux

With methanol; water; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In methanol; water; dimethyl sulfoxide; ethyl acetate;

DOI:10.1021/ol302970c

upstream raw materials:

2-Methylcyclohexanone

(R)-5-acetoxy-1-chlorohexane

(R)-6-chlorohexan-2-ol

(R)-(-)-7-octen-2-ol

Downstream raw materials:

4-nitrobenzyl (R)-6-hydroxyheptanoate

4-nitrobenzyl (S)-6-mesyloxyheptanoate

4-nitrobenzyl (R)-6-mesyloxyheptanoate