Z-L-prolinal semicarbazone

Base Information

• Chemical Name: Z-L-prolinal semicarbazone
• CAS No.: 108807-54-1
• Molecular Formula: C₁₄H₁₈N₄O₃
• Molecular Weight: 290.322
• Mol file: 108807-54-1.mol

Synonyms:

Chemical Property of Z-L-prolinal semicarbazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-L-prolinal semicarbazone

There total 4 articles about Z-L-prolinal semicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

semicarbazide hydrochloride (563-41-7) + (S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester (71461-30-8) → Z-L-prolinal semicarbazone (108807-54-1)

Guidance literature:

With sodium acetate; In ethanol; at 80 ℃; for 0.116667h; Yield given;

DOI:10.1248/cpb.34.2931

Reference yield:

semicarbazide hydrochloride (563-41-7) + (2R)-(+)-phenylmethyl 2-formylpyrrolidine-1-carboxylate (50463-82-6,71461-30-8,105706-84-1,143393-11-7) → Z-D-prolinal semicarbazone (108807-54-1)

Guidance literature:

With sodium acetate; In ethanol; at 80 ℃; for 0.116667h; Yield given;

DOI:10.1248/cpb.34.2931

Reference yield:

N-carbobenzyloxy-L-proline methyl ester (5211-23-4) → Z-L-prolinal semicarbazone (108807-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.76 M diisobutylaluminum hydride / hexane / 30 °C

2: sodium acetate / aq. ethanol / 0.12 h / 80 °C

With sodium acetate; diisobutylaluminium hydride; In ethanol; hexane;

DOI:10.1248/cpb.34.2931

upstream raw materials:

semicarbazide hydrochloride

(2R)-(+)-phenylmethyl 2-formylpyrrolidine-1-carboxylate

methyl (2R)-(benzyloxycarbonyl)pyrrolidine-2-carboxylate

(S)-2-formylpyrrolidine-1-carboxylic acid benzyl ester

Downstream raw materials:

Z-L-Phe-L-prolinal

Z-D-Phe-L-prolinal

Z-L-Val-L-prolinal semicarbazone

Z-L-Ile-L-prolinal

Refernces