5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide

Base Information

• Chemical Name: 5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide
• CAS No.: 556066-76-3
• Molecular Formula: C₂₆H₂₅ClN₄O₇S
• Molecular Weight: 573.026
• Mol file: 556066-76-3.mol

Synonyms:

Chemical Property of 5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide

There total 1 articles about 5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C6H7N2O2S(1-)*K(1+) + 4,6-dichloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidine → 5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide (556066-76-3)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃;

DOI:10.1016/S0960-894X(02)01083-1

Reference yield:

ethanolamine (141-43-5) + 5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide (556066-76-3) → 5-methyl-pyridine-2-sulfonic acid [6-(2-amino-ethoxy)-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide (556066-97-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/S0960-894X(02)01083-1

Reference yield:

5-methyl-pyridine-2-sulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide (556066-76-3) → 5-methyl-pyridine-2-sulfonic acid [5-(2-methoxy-phenoxy)-6-[2-(thiophene-2-sulfonylamino)-ethoxy]-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran; dimethylformamide / 0 - 20 °C

2: base / CH₂Cl₂ / 20 °C

With sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)01083-1

Downstream raw materials:

5-methyl-pyridine-2-sulfonic acid [6-(2-amino-ethoxy)-5-(2-methoxy-phenoxy)-2-(3,4,5-trimethoxy-phenyl)-pyrimidin-4-yl]-amide