1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetyl-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl

Base Information

• Chemical Name: 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetyl-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl
• CAS No.: 642097-80-1
• Molecular Formula: C₅₆H₇₀N₉O₁₃S
• Molecular Weight: 1109.29
• Mol file: 642097-80-1.mol

Synonyms:

Chemical Property of 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetyl-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetyl-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl

There total 4 articles about 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetyl-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine (14384-45-3) → 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetyl-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl (642097-80-1)

Guidance literature:

Multi-step reaction with 5 steps

1: PbO₂

2: EtONa / tetrahydrofuran

3: aq. NaOH

4: 90 percent / DCC; NMM

With 4-methyl-morpholine; sodium hydroxide; sodium ethanolate; lead dioxide; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2003.08.041

Reference yield:

1,3-dihydroxyl-2-(4'-hydroxyphen-1'-yl)-4,4,5,5-tetramethylimidazolidine (38577-52-5) → 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetyl-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl (642097-80-1)

Guidance literature:

Multi-step reaction with 4 steps

1: PbO₂

2: EtONa / tetrahydrofuran

3: aq. NaOH

4: 90 percent / DCC; NMM

With 4-methyl-morpholine; sodium hydroxide; sodium ethanolate; lead dioxide; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2003.08.041

Reference yield:

Boc-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl (199166-46-6) → 1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetyl-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl (642097-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl

2: 90 percent / DCC; NMM

With 4-methyl-morpholine; hydrogenchloride; dicyclohexyl-carbodiimide;

DOI:10.1016/j.bmcl.2003.08.041

upstream raw materials:

N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine

1,3-dihydroxyl-2-(4'-hydroxyphen-1'-yl)-4,4,5,5-tetramethylimidazolidine

Boc-Arg(Tos)-Gly-Asp(OcHex)-Phe-OBzl

1-(1',3'-dioxyl-4',4',5',5'-tetramethyldihydroimidazol-2'-yl)-phenyl-4-yloxylacetic ethyl ester