2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide

Base Information

• Chemical Name: 2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide
• CAS No.: 473465-51-9
• Molecular Formula: C₁₆H₁₃Cl₂N₅O₂S₂
• Molecular Weight: 442.35
• Mol file: 473465-51-9.mol

Synonyms:

Chemical Property of 2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide

There total 3 articles about 2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

benzaldehyde (100-52-7) + N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide (473465-38-2) → 2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide (473465-51-9)

Guidance literature:

In acetic acid; for 5h; Heating;

DOI:10.1002/hc.10037

Reference yield:

2,5-dichlorobenzenesulphonyl chloride (5402-73-3) → 2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide (473465-51-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 10 percent sodium hydroxide / diethyl ether / 3 h / 20 °C

2: 74 percent / 0.25 h / 180 °C

3: 79 percent / acetic acid / 5 h / Heating

With sodium hydroxide; In diethyl ether; acetic acid;

DOI:10.1002/hc.10037

Reference yield:

(2,5-dichloro-benzenesulfonylamino)-acetic acid (109518-76-5) → 2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide (473465-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / 0.25 h / 180 °C

2: 79 percent / acetic acid / 5 h / Heating

In acetic acid;

DOI:10.1002/hc.10037

upstream raw materials:

benzaldehyde

N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide

2,5-dichlorobenzenesulphonyl chloride

(2,5-dichloro-benzenesulfonylamino)-acetic acid