Ethanethioic acid, (phenylmethoxy)-, S-2-pyridinyl ester

Base Information

• Chemical Name: Ethanethioic acid, (phenylmethoxy)-, S-2-pyridinyl ester
• CAS No.: 139007-45-7
• Molecular Formula: C14H13NO2S
• Molecular Weight: 259.32400
• Mol file: 139007-45-7.mol

Synonyms:S-2-pyridylbenzyloxythioacetate;Benzyloxy-thioacetic acid S-pyridin-2-yl ester;

Chemical Property of Ethanethioic acid, (phenylmethoxy)-, S-2-pyridinyl ester

Chemical Property:

• PSA: 64.49000
• LogP: 2.91710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethanethioic acid, (phenylmethoxy)-, S-2-pyridinyl ester

There total 1 articles about Ethanethioic acid, (phenylmethoxy)-, S-2-pyridinyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Sulfanylpyridine (2637-34-5,73018-10-7) + Benzyloxyacetyl chloride (19810-31-2) → S-(2-Pyridyl) 2-(phenylmethoxy)ethanethioate (139007-45-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4020(01)96198-8

Reference yield: 91.0%

(S)-N-benzylidene(1-phenylethylamine) (3129-98-4,17480-71-6,56941-77-6,62696-51-9,69350-13-6,89103-76-4,98393-39-6) + S-(2-Pyridyl) 2-(phenylmethoxy)ethanethioate (139007-45-7) → 1-<(1S)-1-phenylethyl>-3-phenylmethoxy-4-phenylazetidin-2-one

Guidance literature:

With titanium tetrachloride; triethylamine; In dichloromethane; -78 deg C then 0 deg C;

DOI:10.1016/S0040-4020(01)85521-6

Reference yield: 84.0%

methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) + S-(2-Pyridyl) 2-(phenylmethoxy)ethanethioate (139007-45-7) → N-benzyloxyacetyl-(S)-phenylalanine methyl ester (216592-78-8)

Guidance literature:

With trimethylaluminum; In dichloromethane; toluene; at 0 ℃;

DOI:10.1016/j.tet.2005.07.111

upstream raw materials:

2-Sulfanylpyridine

Benzyloxyacetyl chloride

Downstream raw materials:

1-Benzyl-3-benzyloxy-4-phenyl-azetidin-2-one

3-benzyloxy-4-cyclohexylmethyl-1-<(S)-1-phenylethyl>-2-azetidinone

(3R,4R)-3-Benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-(4-methoxy-phenyl)-azetidin-2-one

(3R,4S)-3-(Benzyloxy)-4-<(S)-2,2-dimethyl-1,3-dioxolan-4-yl>-1-(4-methoxyphenyl)azetidin-2-one