11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Base Information

• Chemical Name: 11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester
• CAS No.: 1062278-88-9
• Molecular Formula: C₆₃H₁₀₁N₉O₁₁
• Molecular Weight: 1160.55
• Mol file: 1062278-88-9.mol

Synonyms:

Chemical Property of 11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

There total 6 articles about 11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

11-[3-(4,8-bis-tert-butoxycarbonyl-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl)-benzyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (918907-56-9) + 5-(chloromethyl)quinolin-8-ol (10136-57-9) → 11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (1062278-88-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1016/j.bmcl.2006.08.114

Reference yield:

11-(3-bromomethyl-benzyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (305846-66-6) → 11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (1062278-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile

2: K₂CO₃ / acetonitrile / 20 °C

With potassium carbonate; In acetonitrile;

DOI:10.1016/j.bmcl.2006.08.114

Reference yield:

1,4,8,11-Tetraazacyclotetradecane (295-37-4) → 11-{3-[4,8-bis-tert-butoxycarbonyl-11-(8-hydroxy-quinolin-5-ylmethyl)-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl]-benzyl}-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (1062278-88-9)

Guidance literature:

Multi-step reaction with 4 steps

1: CH₂Cl₂ / 20 °C

2: K₂CO₃ / dimethylformamide / 72 h / 20 °C

3: K₂CO₃ / acetonitrile

4: K₂CO₃ / acetonitrile / 20 °C

With potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2006.08.114

upstream raw materials:

11-[3-(4,8-bis-tert-butoxycarbonyl-1,4,8,11tetraaza-cyclotetradec-1-ylmethyl)-benzyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

5-(chloromethyl)quinolin-8-ol

11-(3-bromomethyl-benzyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

1,4,8,11-Tetraazacyclotetradecane

Refernces