5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE

Base Information

• Chemical Name: 5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE
• CAS No.: 10136-57-9
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.633
• Hs Code.: 2933499090
• Mol file: 10136-57-9.mol

Synonyms:5-Chloromethyl-8-hydroxyquinoline;5-Chloromethyl-8-quinolinol;5-(chloromethyl)quinolin-8-ol;

Chemical Property of 5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.41E-06mmHg at 25°C
• Melting Point: 180 °C
• Refractive Index: 1.677
• Boiling Point: 388.1 ºC at 760 mmHg
• PKA: 4.58±0.10(Predicted)
• Flash Point: 188.5 ºC
• PSA: 33.12000
• Density: 1.355 g/cm³
• LogP: 3.48120
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-(Chloromethyl)quinolin-8-ol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE

There total 3 articles about 5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

8-quinolinol (148-24-3,24804-14-6) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 5-(chloromethyl)quinolin-8-ol (10136-57-9)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃; for 12h;

DOI:10.1002/jhet.2642

Reference yield:

5-(hydroxymethyl)-8-hydroxyquinoline (4053-44-5) → 5-(chloromethyl)quinolin-8-ol (10136-57-9)

Guidance literature:

With thionyl chloride; at 20 ℃; for 6h;

DOI:10.1016/j.tet.2008.09.081

Reference yield:

→ 5-(chloromethyl)quinolin-8-ol (10136-57-9)

Guidance literature:

8-Chinolyl-acetat, H2CO, HCl, HCl-Gas;

upstream raw materials:

8-quinolinol

formaldehyd

5-(hydroxymethyl)-8-hydroxyquinoline

Downstream raw materials:

5-(aminomethyl)-8-hydroxyquinoline

5-(((1-benzylpiperidin-4-yl)(prop-2-ynyl)amino)methyl)quinolin-8-ol

2-(1-benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-ynyl)amino)acetonitrile

5-(((2-(1-benzylpiperidin-4-yl)ethyl)(prop-2-ynyl)amino)methyl)quinolin-8-ol

Refernces

• 1、 Lashgari, Negar,Badiei, Alireza,Mohammadi Ziarani, Ghodsi. "A Fluorescent Sensor for Al(III) and Colorimetric Sensor for Fe(III) and Fe(II) Based on a Novel 8-Hydroxyquinoline Derivative". . p. 1885 - 1894. Retrieved 2016.
• 2、 Yang, Xuelian,Cai, Pei,Liu, Qiaohong,Wu, Jiajia,Yin, Yong,Wang, Xiaobing,Kong, Lingyi. "Novel 8-hydroxyquinoline derivatives targeting β-amyloid aggregation, metal chelation and oxidative stress against Alzheimer's disease". . p. 3191 - 3201. Retrieved 2018.
• 3、 Verma, Rohini,Baral, Minati,Kanungo. "Computational and experimental studies on the effect of conformational flexibility on bonding and photophysics of a triaza-macrocycle tripod". . p. 253 - 273. Retrieved 2021.
• 4、 -. "Green light material as well as preparation method and application thereof". Paragraph 0032; 0037-0042. . Retrieved 2021/07/14.
• 5、 -. "8-hydroxyquinoline quaternary ammonium salt as well as preparation method and application thereof". Paragraph 0041-0044. . Retrieved 2019/10/01.