C₃₇H₄₃N₅O₇

Base Information

• Chemical Name: C₃₇H₄₃N₅O₇
• CAS No.: 1400442-92-3
• Molecular Formula: C₃₇H₄₃N₅O₇
• Molecular Weight: 669.778
• Mol file: 1400442-92-3.mol

Synonyms:

Chemical Property of C₃₇H₄₃N₅O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₄₃N₅O₇

There total 6 articles about C₃₇H₄₃N₅O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C28H36N4O6 (1400442-76-3) → C37H43N5O7 (1400442-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm300947s

Reference yield:

C28H34N4O5 (1400442-82-1) → C37H43N5O7 (1400442-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm300947s

Reference yield:

C19H22N2O3*C2HF3O2 (1400442-56-9) → C37H43N5O7 (1400442-92-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 3 h / 0 - 20 °C / Inert atmosphere

2.2: pH 3 / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

5.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

With 4-methyl-morpholine; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm300947s

upstream raw materials:

C₂₈H₃₆N₄O₆

C₂₈H₃₄N₄O₅

C₁₉H₂₂N₂O₃*C₂HF₃O₂

Boc-D-Phe-OH

Downstream raw materials:

C₃₂H₃₅N₅O₅*C₂HF₃O₂