(R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide

Base Information

Chemical Name:(R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide
CAS No.:1091682-30-2
Molecular Formula:C₂₈H₄₃FN₄O₄
Molecular Weight:518.672
Hs Code.:

(R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide

Chemical Property:

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Useful:

Technology Process of (R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide

There total 9 articles about (R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₃H₅₅FN₄O₆

: 1091682-30-2
(R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃;
DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

: C₂₀H₂₃FN₂O₂*ClH

: 1091682-30-2
(R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: hydrogenchloride / water; ethyl acetate / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4: hydrogen; palladium on activated charcoal / ethanol / 20 °C

With hydrogenchloride; dmap; palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

: C₂₅H₃₁FN₂O₄

: 1091682-30-2
(R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water; ethyl acetate / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: hydrogenchloride / water; ethyl acetate / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5: hydrogen; palladium on activated charcoal / ethanol / 20 °C

With hydrogenchloride; dmap; palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2016.04.086