[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-fluoro-benzyl)-carbamic acid benzyl ester hydrochloride

Base Information

• Chemical Name: [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-fluoro-benzyl)-carbamic acid benzyl ester hydrochloride
• CAS No.: 1091682-31-3
• Molecular Formula: C₂₆H₃₄FN₃O₃*ClH
• Molecular Weight: 492.034
• Mol file: 1091682-31-3.mol

Synonyms:

Chemical Property of [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-fluoro-benzyl)-carbamic acid benzyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-fluoro-benzyl)-carbamic acid benzyl ester hydrochloride

There total 6 articles about [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-fluoro-benzyl)-carbamic acid benzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H42FN3O5 → [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-fluoro-benzyl)-carbamic acid benzyl ester hydrochloride (1091682-31-3)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

C20H23FN2O2*ClH → [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-fluoro-benzyl)-carbamic acid benzyl ester hydrochloride (1091682-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; ethyl acetate;

DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

C25H31FN2O4 → [1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-fluoro-benzyl)-carbamic acid benzyl ester hydrochloride (1091682-31-3)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / water; ethyl acetate / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; ethyl acetate;

DOI:10.1016/j.bmcl.2016.04.086

upstream raw materials:

tert-butyl 4-{[(4-fluorophenyl)methyl]amino}piperidine-1-carboxylate

1-(tert-butoxycarbonyl)-4-aminopiperidine

4-fluorobenzaldehyde

Downstream raw materials:

(R)-2-cyclopentylmethyl-N-{(S)-1-[4-(4-fluoro-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-3-(formyl-hydroxy-amino)-propionamide