C₉H₁₈N₂

Base Information

• Chemical Name: C₉H₁₈N₂
• CAS No.: 1277168-71-4
• Molecular Formula: C₉H₁₈N₂
• Molecular Weight: 154.255
• Mol file: 1277168-71-4.mol

Synonyms:

Chemical Property of C₉H₁₈N₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₁₈N₂

There total 17 articles about C₉H₁₈N₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S)-4-aminohexahydro-2H-quinolizin-1(6H)-one → C9H18N2 (1277168-71-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 23 ℃; for 4h;

DOI:10.3987/COM-18-S(T)66

Reference yield:

epilupininic acid (26892-59-1) → C9H18N2 (1277168-71-4)

Guidance literature:

(1S,9aR)-octahydro-1H-quinolizine-1-carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; Inert atmosphere; Reflux;

With hydrogenchloride; In water; for 0.5h; Inert atmosphere;

DOI:10.1016/j.tet.2011.07.017

Reference yield:

(E)-(7-tert-butoxycarbonylamino)-2-heptenal (1000806-51-8) → C9H18N2 (1277168-71-4)

Guidance literature:

Multi-step reaction with 10 steps

1.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; benzoic acid / chloroform / 22 h / -50 °C / Inert atmosphere

2.1: sodium dihydrogenphosphate; sodium chlorite; dihydrogen peroxide / methanol; water; acetonitrile / 3 h / 0 - 20 °C / Inert atmosphere

3.1: methanol / diethyl ether; toluene / 3 h / 0 - 20 °C / Inert atmosphere

4.1: lithium diisopropyl amide / diethyl ether / 1 h / -100 °C / Inert atmosphere

4.2: 1 h / -100 °C / Inert atmosphere

5.1: dimethylsulfide borane complex / hexane / 0 °C / Inert atmosphere

5.2: 1 h / Inert atmosphere; Reflux

6.1: triethylamine / dichloromethane / 2 h / Inert atmosphere

7.1: 1.5 h / 20 °C / Inert atmosphere

8.1: sodium hydroxide / dichloromethane; water / Inert atmosphere

9.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 0 - 20 °C / Inert atmosphere

10.1: diphenyl phosphoryl azide; triethylamine / toluene / Inert atmosphere; Reflux

10.2: 0.5 h / Inert atmosphere

With (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; methanol; sodium chlorite; sodium dihydrogenphosphate; lithium hydroxide monohydrate; dimethylsulfide borane complex; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine; benzoic acid; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; water; toluene; acetonitrile; 1.1: aza-Michael reaction;

DOI:10.1016/j.tet.2011.07.017

upstream raw materials:

(E)-(7-tert-butoxycarbonylamino)-2-heptenal

(R)-tert-butyl 2-[(R)-1-(methoxycarbonyl)-4-hydroxybutyl]piperidine-1-carboxylate

epilupininic acid

(1R)-(9aR)-octahydro-quinolizine-1-carboxylic acid methyl ester