N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide

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Chemical Name:N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide
CAS No.:190779-86-3
Molecular Formula:C₇₁H₆₉N₅O₁₃
Molecular Weight:1200.35
Hs Code.:

N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide

There total 11 articles about N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4005-49-6
N-benzoyladenine

: 190779-86-3
N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 6 h / Heating

2: 52 percent / TMSOTf / 1,2-dichloro-ethane / 16 h / Heating

3: 96 percent / t-BuOK / dioxane; methanol / 0.02 h / Ambient temperature

4: TBAF / dioxane / 2 h / 50 °C

5: pyridine / 3 h / Ambient temperature

With pyridine; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; tetrabutyl ammonium fluoride; In 1,4-dioxane; methanol; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4020(97)00309-8

Reference yield:

: 18055-47-5
N-Benzoyl-N,9-bis(trimethylsilyl)adenin

: 190779-86-3
N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / TMSOTf / 1,2-dichloro-ethane / 16 h / Heating

2: 96 percent / t-BuOK / dioxane; methanol / 0.02 h / Ambient temperature

3: TBAF / dioxane / 2 h / 50 °C

4: pyridine / 3 h / Ambient temperature

With pyridine; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; tetrabutyl ammonium fluoride; In 1,4-dioxane; methanol; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4020(97)00309-8

Reference yield:

: 190779-52-3
ethyl-3,4,6-tri-O-acetyl-2-O-benzyl-1-thio-D-glucopyranoside

: 190779-86-3
N-(9-{(R)-2-{(2S,3R,4S,5S,6R)-3-Benzyloxy-6-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4,5-dihydroxy-tetrahydro-pyran-2-yloxy}-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-ethoxymethyl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 9 steps

1: 72 percent / NIS, TfOH / diethyl ether / 2 h / Ambient temperature

2: 87 percent / CAN / acetonitrile; H₂O / 0.5 h / Ambient temperature

3: 62 percent / DMAP / pyridine / 48 h / 60 °C

4: 63 percent / 2,6-lutidine, BPO / acetonitrile / 0.5 h / Ambient temperature

5: 85 percent / NIS / 1,2-dichloro-ethane; tetrahydrofuran / 0.08 h / 0 °C

6: 52 percent / TMSOTf / 1,2-dichloro-ethane / 16 h / Heating

7: 96 percent / t-BuOK / dioxane; methanol / 0.02 h / Ambient temperature

8: TBAF / dioxane / 2 h / 50 °C

9: pyridine / 3 h / Ambient temperature

With pyridine; 2,6-dimethylpyridine; dmap; N-iodo-succinimide; ammonium cerium(IV) nitrate; trifluorormethanesulfonic acid; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; tetrabutyl ammonium fluoride; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; diethyl ether; water; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1016/S0040-4020(97)00309-8