C₂₀H₂₃NO₄

Base Information

• Chemical Name: C₂₀H₂₃NO₄
• CAS No.: 6877-26-5
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 6877-26-5.mol

Synonyms:

Chemical Property of C₂₀H₂₃NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₃NO₄

There total 19 articles about C₂₀H₂₃NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(R)-10-benzyloxy-2,3,9-trimethoxytetrahydroprotoberberine (1422431-59-1) → C20H23NO4 (6877-26-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 2h; Reflux;

DOI:10.1016/j.bmc.2012.12.016

Reference yield:

(S)-10-(benzyloxy)-2,3,9-trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinoline (1422431-58-0) → C20H23NO4 (6877-26-5) + (-)-corydalmine (30413-84-4)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; In methanol; ethyl acetate; at 15 - 30 ℃; Reagent/catalyst; Temperature; Overall yield = 85 percent; Optical yield = 80 percent ee;

Reference yield:

C27H30ClNO4 → C20H23NO4 (6877-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / dichloromethane / 1.5 h / 20 °C

2: hydrogenchloride / water; ethanol / 2 h / Reflux

With hydrogenchloride; sodium hydrogencarbonate; In ethanol; dichloromethane; water;

DOI:10.1016/j.bmc.2012.12.016

upstream raw materials:

C₂₇H₃₁NO₅

C₂₉H₃₃NO₆

(R)-10-benzyloxy-2,3,9-trimethoxytetrahydroprotoberberine

(S)-(3-(benzyloxy)-6-((6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-methoxyphenyl)methanol

Refernces

• 1、 Sun, Haifeng,Zhu, Liyuan,Yang, Huicui,Qian, Wangke,Guo, Lin,Zhou, Shengbin,Gao, Bo,Li, Zeng,Zhou, Yu,Jiang, Hualiang,Chen, Kaixian,Zhen, Xuechu,Liu, Hong. "Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile". . p. 856 - 868. Retrieved 2013/03/13.