Technology Process of N-((11-(4-(benzyloxy)-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl)sulfonyl)acetylmethanesulfonamide
There total 9 articles about N-((11-(4-(benzyloxy)-2-chlorophenyl)-6-hydroxy-3,3-dimethyl-1-oxo-1,2,3,4,5,11-hexahydrodibenzo[b,e][1,4]diazepin-10-yl)sulfonyl)acetylmethanesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h / 20 °C
2.1: toluene / Heating / reflux
3.1: acetic acid / ethanol / 12 h / Heating / reflux
4.1: potassium tert-butylate / tetrahydrofuran / 0.27 h / 0 °C
4.2: 1.17 h / 0 - 20 °C
5.1: sodium hydride / tetrahydrofuran / 36 h / 0 - 20 °C
6.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
6.2: 12 h / 0 °C
With
potassium tert-butylate; hydrogen; sodium hydride; acetic acid;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene / Heating / reflux
2.1: acetic acid / ethanol / 12 h / Heating / reflux
3.1: potassium tert-butylate / tetrahydrofuran / 0.27 h / 0 °C
3.2: 1.17 h / 0 - 20 °C
4.1: sodium hydride / tetrahydrofuran / 36 h / 0 - 20 °C
5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
5.2: 12 h / 0 °C
With
potassium tert-butylate; sodium hydride; acetic acid;
In
tetrahydrofuran; ethanol; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C
2.1: acetic acid / ethanol / 12 h / Heating / reflux
3.1: potassium tert-butylate / tetrahydrofuran / 0.27 h / 0 °C
3.2: 1.17 h / 0 - 20 °C
4.1: sodium hydride / tetrahydrofuran / 36 h / 0 - 20 °C
5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C
5.2: 12 h / 0 °C
With
potassium tert-butylate; sodium hydride; caesium carbonate; acetic acid;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
