19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide

Base Information

Chemical Name:19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide
CAS No.:1208129-89-8
Molecular Formula:C₃₁H₄₀N₄O₇S
Molecular Weight:612.747
Hs Code.:

19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide

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Chemical Property of 19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide

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Technology Process of 19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide

There total 8 articles about 19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879498-90-5
1H-indole-6-carboxylic acid, 2-bromo-3-cyclohexyl-, 1,1-dimethylethyl ester

: 1208129-89-8
19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydride / tetrahydrofuran / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 12 h / 100 °C

3: potassium carbonate / acetonitrile / 20 °C

4: water; lithium hydroxide / tetrahydrofuran; methanol

5: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran

6: sulfonamide / 1,4-dioxane / 0.75 h / 100 °C

7: trifluoroacetic acid / dichloromethane / 20 °C

8: acetonitrile

9: 1,8-diazabicyclo[5.4.0]undec-7-ene

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfonamide; water; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetonitrile; 2: Suzuki-Miyaura reaction;
DOI:10.1016/j.bmcl.2012.03.097

Reference yield:

: C₂₉H₃₅NO₆

: 1208129-89-8
19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran

2: sulfonamide / 1,4-dioxane / 0.75 h / 100 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: acetonitrile

5: 1,8-diazabicyclo[5.4.0]undec-7-ene

With sulfonamide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.03.097

Reference yield:

: 1384353-42-7
C₃₅H₄₉N₃O₆

: 1208129-89-8
19-trimethyl-5,6,9,10-tetrahydro-2H,8H-14,18:17,20-di(metheno)-1,7,11,4,10,12,19-benzodioxathiatetraazacyclodocosine-3,13(4H,12h,19H)-dione 11,11-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfonamide / 1,4-dioxane / 0.75 h / 100 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: acetonitrile

4: 1,8-diazabicyclo[5.4.0]undec-7-ene

With sulfonamide; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.03.097