3-((1R,5S)-2-(((1'R,2'S)-2-phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol

Base Information

Chemical Name:3-((1R,5S)-2-(((1'R,2'S)-2-phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol
CAS No.:1265968-43-1
Molecular Formula:C₂₄H₂₉NO
Molecular Weight:347.5
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-((1R,5S)-2-(((1'R,2'S)-2-phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol

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Technology Process of 3-((1R,5S)-2-(((1'R,2'S)-2-phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol

There total 11 articles about 3-((1R,5S)-2-(((1'R,2'S)-2-phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 1265968-43-1
3-((1R,5S)-2-(((1'R,2'S)-2-phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 20 h / 20 °C

2.1: potassium cyanide; cobalt(II) chloride hexahydrate; nickel(II) cyanide tetrahydrate; hydrogen; potassium hydroxide / toluene / 2 h / 95 °C

2.2: 48 h / 95 °C

3.1: methanol; water / Heating

4.1: sodium hydrogencarbonate / water

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

7.1: hydrogen bromide; acetic acid / water / Reflux; Inert atmosphere

With potassium cyanide; nickel(II) cyanide tetrahydrate; cobalt(II) chloride hexahydrate; N-benzyl-N,N,N-triethylammonium chloride; hydrogen bromide; hydrogen; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/jm1011676

Reference yield:

: 51596-47-5
1R,5S-(+)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

: 1265968-43-1
3-((1R,5S)-2-(((1'R,2'S)-2-phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3: hydrogen bromide; acetic acid / water / Reflux; Inert atmosphere

With hydrogen bromide; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm1011676

Reference yield:

: 42916-17-6
((1R,4aS)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methanaminium (1R,2S)-2-phenylcyclopropane-1-carboxylate

: 1265968-43-1
3-((1R,5S)-2-(((1'R,2'S)-2-phenylcyclopropyl)methyl)-2-azabicyclo[3.3.1]nonan-5-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / water

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

3: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: hydrogen bromide; acetic acid / water / Reflux; Inert atmosphere

With hydrogen bromide; sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm1011676