(R)-3-AMino-1-Methyl-piperidine dihydrochloride

Base Information

• Chemical Name: (R)-3-AMino-1-Methyl-piperidine dihydrochloride
• CAS No.: 1157849-50-7
• Molecular Formula: C₆H₁₄N₂*ClH
• Molecular Weight: 150.651
• Hs Code.: 2933399990
• Mol file: 1157849-50-7.mol

Synonyms:

Chemical Property of (R)-3-AMino-1-Methyl-piperidine dihydrochloride

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(3R)-1-Methylpiperidin-3-amineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (3R)-1-Methylpiperidin-3-amine Dihydrochloride can be used as PCAF and GCN5 inhibitors to treat cancer.

Technology Process of (R)-3-AMino-1-Methyl-piperidine dihydrochloride

There total 11 articles about (R)-3-AMino-1-Methyl-piperidine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-tert-butyl (1-methylpiperidin-3-yl)carbamate → (R)-1-methylpiperidin-3-amine dihydrochloride (1157849-50-7,1157849-51-8)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; at 80 ℃; for 1h;

DOI:10.1021/acs.jmedchem.6b01566

Reference yield: 84.0%

(S)-tert-butyl (1-methylpiperidin-3-yl)carbamate (902152-77-6) → (S)-1-methylpiperidin-3-amine dihydrochloride (1157849-50-7,1157849-51-8)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; at 50 ℃; for 0.0833333h;

DOI:10.1021/acs.jmedchem.6b01566

Reference yield:

tert‐butyl 3‐aminopiperidine‐1‐carboxylate (144243-24-3) → 3-amino-1-methylpiperidinedihydrochloride (1157849-50-7,1157849-51-8)

Guidance literature:

tert‐butyl 3‐aminopiperidine‐1‐carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 14.25h; Heating / reflux;

With hydrogenchloride; In 1,4-dioxane;

upstream raw materials:

tert‐butyl 3‐aminopiperidine‐1‐carboxylate

L-glutamic acid

[(1S)-4-hydroxy-1-(hydroxymethyl)butyl]carbamic acid tert-butyl ester

(S)-tert-butyl (1-methylpiperidin-3-yl)carbamate

Downstream raw materials:

(S)-1-(1-methylpiperidine-3-yl)-3-phenylurea

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