BENZYL METHYL(PIPERIDIN-4-YL)CARBAMATE HYDROCHLORIDE

Base Information

• Chemical Name: BENZYL METHYL(PIPERIDIN-4-YL)CARBAMATE HYDROCHLORIDE
• CAS No.: 139062-98-9
• Molecular Formula: C14H20N2O2.ClH
• Molecular Weight: 284.78200
• Hs Code.: 2933399090
• Mol file: 139062-98-9.mol

Synonyms:Benzyl methyl(piperidin-4-yl)carbamate hydrochloride;W3386;Benzyl piperidin-4-ylmethylcarbamate hydrochloride;I14-5652;

Chemical Property of BENZYL METHYL(PIPERIDIN-4-YL)CARBAMATE HYDROCHLORIDE

Chemical Property:

• PSA: 41.57000
• LogP: 3.13780

Purity/Quality:

≥99% ^*data from raw suppliers

Benzylmethyl(piperidin-4-yl)carbamatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZYL METHYL(PIPERIDIN-4-YL)CARBAMATE HYDROCHLORIDE

There total 9 articles about BENZYL METHYL(PIPERIDIN-4-YL)CARBAMATE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

→ piperidin-4-ylmethyl-carbamic acid benzyl ester hydrochloride (139062-98-9)

Guidance literature:

Reference yield: 72.0%

4-(((benzyloxy)carbonyl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester (847039-05-8) → piperidin-4-ylmethyl-carbamic acid benzyl ester hydrochloride (139062-98-9)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b00794

Reference yield:

4-bromo-1H-piperidine (90633-18-4) → piperidin-4-ylmethyl-carbamic acid benzyl ester hydrochloride (139062-98-9)

Guidance literature:

Multi-step reaction with 6 steps

1: DIPEA / CH₂Cl₂

2: NaN₃ / dimethylformamide / 20 °C

3: H₂ / 10 percent Pd/C / methanol / 2068.59 Torr

4: DIPEA / CH₂Cl₂ / 20 °C

5: NaH / dimethylformamide / 20 °C

6: HCl / methanol / 20 °C

With hydrogenchloride; sodium azide; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(01)00492-9

upstream raw materials:

4-(((benzyloxy)carbonyl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

4-bromo-1H-piperidine

1-(tert-butoxycarbonyl)-4-aminopiperidine

tert-butyl 4-bromo-1-piperidinecarboxylate

Refernces

• 1、 Finke, Paul E.,Oates, Bryan,Mills, Sander G.,MacCoss, Malcolm,Malkowitz, Lorraine,Springer, Martin S.,Gould, Sandra L.,DeMartino, Julie A.,Carella, Anthony,Carver, Gwen,Holmes, Karen,Danzeisen, Renee,Hazuda, Daria,Kessler, Joseph,Lineberger, Janet,Miller, Michael,Schleif, William A.,Emini, Emilio A.. "Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: Synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N- (benzyloxycarbonyl)amino)piperidin-1-yl)butanes". . p. 2475 - 2479. Retrieved 2007/10/03.