90633-18-4

Basic information

• Product Name: 4-BROMO-PIPERIDINE
• Synonyms: 4-BROMO-PIPERIDINE
• CAS NO: 90633-18-4
• Molecular Formula: C₅H₁₀BrN
• Molecular Weight: 164.04
• Mol File: 90633-18-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 182℃
• Flash Point: 64℃
• Appearance: /
• Density: 1.40
• PKA: 9.47±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-PIPERIDINE(90633-18-4)
• EPA Substance Registry System: 4-BROMO-PIPERIDINE(90633-18-4)

Safety Data

• Hazardous Substances Data: 90633-18-4(Hazardous Substances Data)

Usage

General Description

4-Bromo-piperidine is a chemical compound with the molecular formula C5H10BrN. It is a piperidine derivative that contains a bromine atom at the 4-position of the piperidine ring. 4-BROMO-PIPERIDINE is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in organic chemistry as a building block for the preparation of various heterocyclic compounds. 4-Bromo-piperidine is a colorless to pale yellow liquid with a characteristic odor. It is mainly produced through the bromination of piperidine and is stored and handled with proper safety precautions due to its potential health hazards.

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 10035-10-6 hydrogen bromide 
• 54288-70-9 4-bromopiperidine hydrobromide 
• 13880-89-2 3-hydroxyglutaronitrile 

Downstream Products

• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 166953-64-6 benzyl 4-bromo-1-piperidinecarboxylate 
• 1158961-44-4 C₂₀H₃₁BrN₂O 
• 1093853-70-3 1,1,1-trifluoro-2-(4-(4-(1-tosylpiperidin-4-yl)oxazol-5-yl)phenyl)propan-2-ol 
• 1093853-71-4 4-(isocyano(tosyl)methyl)-1-tosylpiperidine 
• 146827-60-3 4-(acetylthio)-1-(benzyloxycarbonyl)piperidine 
• 633312-80-8 C₂₈H₃₆N₄O₆S 
• 287953-54-2 4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester 
• 122374-26-9 1-Benzoyl-4-bromopiperidine 
• 1383841-43-7 (4-isopropylpiperidin-1-yl)(phenyl)methanone 
• 1376358-84-7 3-(1-(2-(4-bromopiperidin-1-yl)acetyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-one 
• 1188276-81-4 C₃₄H₄₅N₅O₇ 
• 347885-68-1 4-bromo-1-tosylpiperidine 

Relevant articles and documents

Tritium labelling of a cholesterol amphiphile designed for cell membrane anchoring of proteins

Cell membrane association of proteins can be achieved by the addition of lipid moieties to the polypeptide chain, and such lipid-modified proteins have important biological functions. A class of cell surface proteins contains a complex glycosylphosphatidylinositol (GPI) glycolipid at the C-terminus, and they are accumulated in cholesterol-rich membrane microdomains, that is, lipid rafts. Semisynthetic lipoproteins prepared from recombinant proteins and designed lipids are valuable probes and model systems of the membrane-associated proteins. Because GPI-anchored proteins can be reinserted into the cell membrane with the retention of the biological function, they are appropriate candidates for preparing models via reduction of the structural complexity. A synthetic headgroup was added to the 3β-hydroxyl group of cholesterol, an essential lipid component of rafts, and the resulting cholesterol derivative was used as a simplified GPI mimetic. In order to quantitate the membrane integrated GPI mimetic after the exogenous addition to live cells, a tritium labelled cholesterol anchor was prepared. The radioactive label was introduced into the headgroup, and the radiolabelled GPI mimetic anchor was obtained with a specific activity of 1.37 TBq/mmol. The headgroup labelled cholesterol derivative was applied to demonstrate the sensitive detection of the cell membrane association of the anchor under in vivo conditions.