90633-18-4

Basic information

• Product Name: 4-BROMO-PIPERIDINE
• Synonyms: 4-BROMO-PIPERIDINE
• CAS NO: 90633-18-4
• Molecular Formula: C₅H₁₀BrN
• Molecular Weight: 164.04
• Mol File: 90633-18-4.mol

Chemical Properties

• Boiling Point: 182℃
• Flash Point: 64℃
• Appearance: /
• Density: 1.40
• PKA: 9.47±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-PIPERIDINE(90633-18-4)
• EPA Substance Registry System: 4-BROMO-PIPERIDINE(90633-18-4)

Safety Data

• Hazardous Substances Data: 90633-18-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-PIPERIDINE is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties. Its unique structure allows for the creation of molecules with targeted biological activities, enhancing the effectiveness of medications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-BROMO-PIPERIDINE serves as an essential building block for the synthesis of agrochemicals, including pesticides and herbicides. Its incorporation into these compounds helps improve their efficacy in controlling pests and weeds, thereby increasing crop yields and protecting agricultural produce.
Used in Organic Chemistry:
4-BROMO-PIPERIDINE is utilized as a valuable building block in organic chemistry for the preparation of heterocyclic compounds. Its presence in these compounds allows for the exploration of new chemical reactions and the synthesis of novel molecules with potential applications in various fields, such as materials science and medicinal chemistry.
Safety Precautions:
Due to its potential health hazards, 4-BROMO-PIPERIDINE must be stored and handled with proper safety measures. Adequate personal protective equipment, such as gloves and safety goggles, should be worn during its manipulation to minimize exposure risks. Additionally, it should be kept away from incompatible materials and stored in well-ventilated areas to ensure safe handling and usage.

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 13880-89-2 3-hydroxyglutaronitrile 
• 54288-70-9 4-bromopiperidine hydrobromide 
• 10035-10-6 hydrogen bromide 

Downstream Products

• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 1093853-70-3 1,1,1-trifluoro-2-(4-(4-(1-tosylpiperidin-4-yl)oxazol-5-yl)phenyl)propan-2-ol 
• 1093853-71-4 4-(isocyano(tosyl)methyl)-1-tosylpiperidine 
• 146827-60-3 4-(acetylthio)-1-(benzyloxycarbonyl)piperidine 
• 633312-80-8 C₂₈H₃₆N₄O₆S 
• 287953-54-2 4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester 
• 122374-26-9 1-Benzoyl-4-bromopiperidine 
• 1383841-43-7 (4-isopropylpiperidin-1-yl)(phenyl)methanone 
• 1376358-84-7 3-(1-(2-(4-bromopiperidin-1-yl)acetyl)-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2H-chromen-2-one 
• 1188276-81-4 C₃₄H₄₅N₅O₇ 
• 1158961-44-4 C₂₀H₃₁BrN₂O 
• 347885-68-1 4-bromo-1-tosylpiperidine 
• 166953-64-6 benzyl 4-bromo-1-piperidinecarboxylate 

Relevant articles and documents

Tritium labelling of a cholesterol amphiphile designed for cell membrane anchoring of proteins

Cell membrane association of proteins can be achieved by the addition of lipid moieties to the polypeptide chain, and such lipid-modified proteins have important biological functions. A class of cell surface proteins contains a complex glycosylphosphatidylinositol (GPI) glycolipid at the C-terminus, and they are accumulated in cholesterol-rich membrane microdomains, that is, lipid rafts. Semisynthetic lipoproteins prepared from recombinant proteins and designed lipids are valuable probes and model systems of the membrane-associated proteins. Because GPI-anchored proteins can be reinserted into the cell membrane with the retention of the biological function, they are appropriate candidates for preparing models via reduction of the structural complexity. A synthetic headgroup was added to the 3β-hydroxyl group of cholesterol, an essential lipid component of rafts, and the resulting cholesterol derivative was used as a simplified GPI mimetic. In order to quantitate the membrane integrated GPI mimetic after the exogenous addition to live cells, a tritium labelled cholesterol anchor was prepared. The radioactive label was introduced into the headgroup, and the radiolabelled GPI mimetic anchor was obtained with a specific activity of 1.37 TBq/mmol. The headgroup labelled cholesterol derivative was applied to demonstrate the sensitive detection of the cell membrane association of the anchor under in vivo conditions.

RING INVERSION EQUILIBRIA IN 4-CHLORO-, 4-BROMO-, AND 4-METHOXY-1-ALKYLPIPERIDINES IN A NON-POLAR SOLVENT

The position of ring inversion equilibrium (axial Requuatorial R) in 4-R-N-alkylpiperidines (R = Cl, Br, or OMe), dissolved in CFCl3-CDCl3, has been determined by (13)C n.m.r. spectroscopy at low temperatures.In all three series, change of NH to NMe produces a marked increase in the proportion of conformation with axial R.When R is OMe, further alterations in the N-substituent from Me to Et, Pri, and CH2CF3 do not affect the equilibrium significantly, but the signifficant changes observed when R is halogen can be related to the inductive effect of the N-substituent. (13)C Chemical shifts, proportions of conformations, and conformational free energy differences are recorded for all systems studied.