3-O-trityl-6-O-desmethyl-buprenorphine

Base Information

Chemical Name:3-O-trityl-6-O-desmethyl-buprenorphine
CAS No.:1613511-98-0
Molecular Formula:C₄₇H₅₃NO₄
Molecular Weight:695.942
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-O-trityl-6-O-desmethyl-buprenorphine

Chemical Property:

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Technology Process of 3-O-trityl-6-O-desmethyl-buprenorphine

There total 2 articles about 3-O-trityl-6-O-desmethyl-buprenorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52485-79-7
Buprenorphine

: 1613511-98-0
3-O-trityl-6-O-desmethyl-buprenorphine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

2: triethylamine / dichloromethane

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm500503k

Reference yield:

: 76-83-5
trityl chloride

: 6-O-desmethyl-buprenorphine

: 1613511-98-0
3-O-trityl-6-O-desmethyl-buprenorphine

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm500503k

Reference yield: 20.0%

: 762-49-2
2-fluoroethyl bromide

: 1613511-98-0
3-O-trityl-6-O-desmethyl-buprenorphine

: 1613511-99-1
(5R,6R,7R,9R,13S,14S,20S)-(5α,7α)-17-cyclopropylmethyl-4,5-epoxy-18,19-dihydro-6-(2-fluoroethoxy)-3-triphenylmethoxy-α-(1,1-dimethylethyl)-α-methyl-6,14-ethenomorphinan-7-methanol

: 1613512-01-8
C₄₉H₅₅NO₄

Guidance literature:: 3-O-trityl-6-O-desmethyl-buprenorphine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

2-fluoroethyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm500503k