Apoptolidin

Base Information

Chemical Name:Apoptolidin
CAS No.:194874-06-1
Molecular Formula:C₅₈H₉₆O₂₁
Molecular Weight:1129.39
Hs Code.:
UNII:SAO6WVQ23I
ChEMBL ID:CHEMBL4096158
Metabolomics Workbench ID:106117
Nikkaji Number:J1.230.355F
Wikidata:Q27289111
Mol file:194874-06-1.mol

Synonyms:apoptolidin

Suppliers and Price of Apoptolidin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Apoptolidin
100ug
$ 513.00

TRC
Apoptolidin
250μg
$ 430.00

TRC
Apoptolidin
100μg
$ 215.00

Sigma-Aldrich
Apoptolidin A Ready Made Solution 1?mg/mL in DMSO
500 μL
$ 814.00

Sigma-Aldrich
Apoptolidin A Ready Made Solution 1mg/mL in DMSO
500ul
$ 785.00

Cayman Chemical
Apoptolidin ≥95%
500μg
$ 860.00

Cayman Chemical
Apoptolidin ≥95%
100μg
$ 215.00

American Custom Chemicals Corporation
APOPTOLIDIN 95.00%
0.1MG
$ 436.00

Total 8 raw suppliers

Chemical Property of Apoptolidin

Chemical Property:

Melting Point:128-130°
Flash Point:87℃
PSA：289.67000
LogP:3.58730
Storage Temp.:?20°C
Solubility.:Soluble in DMSO, DMF, ethanol, or methanol.
XLogP3:2.7
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:21
Rotatable Bond Count:15
Exact Mass:1128.64441007
Heavy Atom Count:79
Complexity:2080

Purity/Quality:

97% ^*data from raw suppliers

Apoptolidin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1C=C(C=C(C=C(C(=O)OC(CC(C(CCC=C(C=CC1OC2C(C(C(C(O2)C)OC)O)O)C)O)OC)C(C3(C(C(C(C(O3)CC(COC)OC4CC(C(C(O4)C)OC5CC(C(C(O5)C)O)OC)(C)O)C)O)C)O)O)C)C)C
Isomeric SMILES:C[C@@H]1/C=C(/C=C(/C=C(/C(=O)O[C@@H](C[C@@H]([C@H](CC/C=C(/C=C/[C@H]1O[C@H]2[C@H]([C@@H]([C@H]([C@@H](O2)C)OC)O)O)\C)O)OC)[C@H]([C@]3([C@@H]([C@H]([C@H]([C@H](O3)C[C@H](COC)O[C@H]4C[C@]([C@H]([C@@H](O4)C)O[C@H]5C[C@H]([C@@H]([C@H](O5)C)O)OC)(C)O)C)O)C)O)O)\C)\C)\C
Description Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1?Is believed to act via inhibition of F0F1-ATPase2?but correlation studies indicate that a second mechanism may be the actual mode of action3.? Cell permeable.
Uses Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

Technology Process of Apoptolidin

There total 3 articles about Apoptolidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 795290-14-1
4'''-O-tert-butyldimethylsilyl-21-O-methyl-23O,2'O,3'O,3''O-tetrakis(triethylsilyl)apoptolidin A

: 194874-06-1
apoptolidin

: 27-hydroxy apoptolidin A

Guidance literature:: With fluorosilicic acid; In acetonitrile; at -35 - -5 ℃; for 72h;
DOI:10.1002/chem.200600462

Reference yield:

: 502156-06-1
apoptolidin-C₂₁-methyl ketal

: 194874-06-1
apoptolidin

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; water; at 25 ℃; for 2.5h;
DOI:10.1002/1521-3773(20011015)40:20<3854::AID-ANIE3854>3.0.CO;2-D