2-Bromo-3-fluoro-4-pyridinecarboxylic acid

Base Information

• Chemical Name: 2-Bromo-3-fluoro-4-pyridinecarboxylic acid
• CAS No.: 1211530-89-0
• Molecular Formula: C₆H₃BrFNO₂
• Molecular Weight: 219.998
• Hs Code.: 2933399990
• Mol file: 1211530-89-0.mol

Synonyms:

Chemical Property of 2-Bromo-3-fluoro-4-pyridinecarboxylic acid

Chemical Property:

• Boiling Point: 408.9±45.0 °C(Predicted)
• PKA: 2.05±0.10(Predicted)
• Density: 1.903±0.06 g/cm3 (20 oC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3-fluoroisonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-3-fluoro-4-pyridinecarboxylic acid

There total 1 articles about 2-Bromo-3-fluoro-4-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

2-bromo-3-fluoro-4-methylpyridine (884494-37-5) → 2-bromo-3-fluoroisonicotinic acid (1211530-89-0)

Guidance literature:

With potassium permanganate; In water; for 12h; Reflux;

DOI:10.1021/acs.jmedchem.5b01933

Reference yield:

2-bromo-3-fluoroisonicotinic acid (1211530-89-0) → 2-bromo-3-fluoropyridin-4-amine

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; diphenyl phosphoryl azide / Reflux

2: hydrogenchloride / dichloromethane; isopropyl alcohol / 48 h

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In dichloromethane; isopropyl alcohol;

Reference yield:

2-bromo-3-fluoroisonicotinic acid (1211530-89-0) → C36H43FN2O7Si

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine; isobutyl chloroformate / dichloromethane / 2 h / 0 - 20 °C

2.1: sulfuric acid / 0.5 h / 120 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 2 h / -78 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / 20 °C

4.2: 20 °C

With n-butyllithium; sulfuric acid; triethylamine; lithium hexamethyldisilazane; isobutyl chloroformate; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/acs.jmedchem.5b01933

upstream raw materials:

2-bromo-3-fluoro-4-methylpyridine

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