BMS-986142

Base Information

• Chemical Name: BMS-986142
• CAS No.: 1643368-58-4
• Molecular Formula: C₃₂H₃₀F₂N₄O₄
• Molecular Weight: 572.611
• Mol file: 1643368-58-4.mol

Synonyms:

Chemical Property of BMS-986142

Chemical Property:

• Boiling Point: 746.5±70.0 °C(Predicted)
• Density: 1.394±0.06 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

BMS-986142 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BMS-986142

There total 63 articles about BMS-986142 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-5-bromo-6-fluoro-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide + 8-fluoro-1-methyl-3-(S)-(2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)quinazoline-2,4(1H,3H)-dione → BMS-986142 (1643368-58-4)

Guidance literature:

With potassium phosphate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b01088

Reference yield: 89.4%

propyl (2-((3-((2S)-8-carbamoyl-6-fluoro-2-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazol-5-yl)-2-methylphenyl)carbamoyl)-6-fluorophenyl)(methyl)carbamate → BMS-986142 (1643368-58-4)

Guidance literature:

With lithium tert-butoxide; In 2-methyltetrahydrofuran; at 20 ℃; for 2.25h; Solvent; Reagent/catalyst; Temperature; diastereoselective reaction;

Reference yield: 89.4%

propyl (2-((3-((2S,5R)-8-carbamoyl-6-fluoro-2-((S)-2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazol-5-yl)-2-methylphenyl)carbamoyl)-6-fluorophenyl)(methyl)carbamate → BMS-986142 (1643368-58-4)

Guidance literature:

With lithium tert-butoxide; In tetrahydrofuran; at 25 ℃; for 0.25h;

DOI:10.1021/acs.orglett.8b01218

upstream raw materials:

ethyl 3-oxocyclohexanecarboxylate

ethyl 5-bromo-8-carbamoyl-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylate

8-fluoro-2H-benzo[d][1,3]oxazine-2,4(1H)-dione

3-bromo-2-methylaniline

Refernces

• 1、 -. "PROCESS FOR PREPARING TETRAHYDROCARBAZOLE CARBOXAMIDE COMPOUND". . . Retrieved 2018/07/29.
• 2、 -. "SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLE CARBOXAMIDE COMPOUNDS". Paragraph 0628 - 0630. . Retrieved 2015/01/07.