Technology Process of ethyl 5-bromo-8-carbamoyl-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylate
There total 7 articles about ethyl 5-bromo-8-carbamoyl-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(RS)-5-bromo-2-(ethoxycarbonyl)-6-fluoro-2,3,4,9-tetrahydro-1H-carbazole-8-carboxylic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; dichloromethane;
at 20 ℃;
for 0.333333h;
With
ammonium hydroxide;
In
tetrahydrofuran; dichloromethane;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: acetic acid / toluene / 20 h / 110 °C
1.2: 90 - 94 °C
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 0.33 h / 20 °C
2.2: 1 h / 20 °C
With
benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / Cooling with ice
1.2: 0.75 h / 20 °C
2.1: acetic acid / toluene / 20 h / 110 °C
2.2: 90 - 94 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 0.33 h / 20 °C
3.2: 1 h / 20 °C
With
hydrogenchloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium nitrite;
In
tetrahydrofuran; dichloromethane; water; toluene;
