5-AMino-1-(β-D-ribofuranosyl)iMidazole-4-carboxylic Acid SodiuM Salt

Base Information

• Chemical Name: 5-AMino-1-(β-D-ribofuranosyl)iMidazole-4-carboxylic Acid SodiuM Salt
• CAS No.: 53459-67-9
• Molecular Formula: C₉H₁₂N₃O₆*Na
• Molecular Weight: 281.201
• Mol file: 53459-67-9.mol

Synonyms:

Chemical Property of 5-AMino-1-(β-D-ribofuranosyl)iMidazole-4-carboxylic Acid SodiuM Salt

Chemical Property:

• Melting Point: >100°C (dec.)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Water (Slightly)

Purity/Quality:

5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylicAcidSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylic Acid Sodium Salt is an protected intermediate in the synthesis of purine metabolites.

Technology Process of 5-AMino-1-(β-D-ribofuranosyl)iMidazole-4-carboxylic Acid SodiuM Salt

There total 2 articles about 5-AMino-1-(β-D-ribofuranosyl)iMidazole-4-carboxylic Acid SodiuM Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

AICA riboside (2627-69-2) → sodium 5-amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylate (53459-67-9)

Guidance literature:

With sodium hydroxide; In water; for 4h; Heating;

Reference yield:

→ sodium 5-amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylate (53459-67-9)

Guidance literature:

5-Amino-1-(β-D-ribofuranosyl)-imidazol-4-carboxamid, NaOH;

DOI:10.1021/jm00257a600

Reference yield:

sodium 5-amino-1-(β-D-ribofuranosyl)imidazole-4-carboxylate (53459-67-9) → 7-β-D-ribofuranosylimidazo<4,5-d>-v-triazin-<3N-(p-iodophenyl)>-4-one (119827-71-3)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 5 h / 0 °C

2: 1.) dicyclohexylcarbodiimide; 2.) acetic acid / 1.) DMF, room temp., overnight; 2.) 5 h

3: 78 percent / dimethylformamide / heated, bath temp. 105 deg C, overnight

4: 74 percent / HCl, NaNO₂ / methanol; H₂O / 0.33 h / -40 - -25 °C

5: 80 percent / NH₄OH / methanol / Ambient temperature; overnight

With pyridine; hydrogenchloride; ammonium hydroxide; acetic acid; dicyclohexyl-carbodiimide; sodium nitrite; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570250512

upstream raw materials:

AICA riboside

Downstream raw materials:

N-[5-amino-1-(tri-O-acetyl-β-D-ribofuranosyl)-1H-imidazole-4-carbonyloxy]-succinimide

5-amino-1-β-D-ribofuranosylimidazole-4-

7-β-D-ribofuranosylimidazo<4,5-d>-v-triazin-<3N-(p-iodophenyl)>-4-one

5-amino-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)imidazole-4-

Refernces