Technology Process of (R)-2-(2,4-dichlorobenzyl)-5-oxohexanal
There total 3 articles about (R)-2-(2,4-dichlorobenzyl)-5-oxohexanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 80 °C / Cooling with ice; Inert atmosphere
2: pyridinium chlorochromate / dichloromethane / 4 h / 0 °C
3: (R)-3-benzyl-1-methyl-1,4-diazaspiro[4.4]nonan-2-one; Ethyl protocatechuate / 20 °C
With
lithium aluminium tetrahydride; Ethyl protocatechuate; (R)-3-benzyl-1-methyl-1,4-diazaspiro[4.4]nonan-2-one; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane;
3: |Michael Addition;
DOI:10.1021/ol301874x
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridinium chlorochromate / dichloromethane / 4 h / 0 °C
2: (R)-3-benzyl-1-methyl-1,4-diazaspiro[4.4]nonan-2-one; Ethyl protocatechuate / 20 °C
With
Ethyl protocatechuate; (R)-3-benzyl-1-methyl-1,4-diazaspiro[4.4]nonan-2-one; pyridinium chlorochromate;
In
dichloromethane;
2: |Michael Addition;
DOI:10.1021/ol301874x
- Guidance literature:
-
With
Ethyl protocatechuate; (R)-3-benzyl-1-methyl-1,4-diazaspiro[4.4]nonan-2-one;
at 20 ℃;
Overall yield = 61 %; enantioselective reaction;
DOI:10.1021/ol301874x
