11β,20-dihydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al

Base Information

• Chemical Name: 11β,20-dihydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al
• CAS No.: 105562-12-7
• Molecular Formula: C₂₁H₂₈O₄
• Molecular Weight: 344.451
• Mol file: 105562-12-7.mol

Synonyms:

Chemical Property of 11β,20-dihydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al

Chemical Property:

• Melting Point: 195-200°C

Purity/Quality:

95% min ^*data from raw suppliers

(11β,17E)-11,20-dihydroxy-3-oxo-pregna-4,17(20)-dien-21-al ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (11β,17E)-11,20-dihydroxy-3-oxo-pregna-4,17(20)-dien-21-al is a derivative of cortisol and an isomer of (11β,17Z)-11,20-dihydroxy-3-oxo-pregna-4,17(20)-dien-21-al (D453910). (11β,17E)-11,20-dihydroxy-3-oxo-pregna-4,17(20)-dien-21-al is a useful compound to investigate liver metabolites in mice.

Technology Process of 11β,20-dihydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al

There total 2 articles about 11β,20-dihydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

HYDROCORTISONE (50-23-7) → 11β,20-dihydroxy-3-oxo-4,trans-17(20)-pregnadien-21-al (105562-12-7) + 11β,20-dihydroxy-3-oxo-4,cis-17(20)-pregnadien-21-al (105562-13-8)

Guidance literature:

With toluene-4-sulfonic acid; In 1,4-dioxane; for 1.5h; Heating;

DOI:10.1016/S0040-4039(01)01586-6

Reference yield:

→ 11β,20-Dihydroxy-3,21-dioxo-pregnadien-(4,17(20)) (3247-38-9,105562-12-7,105562-13-8)

Guidance literature:

11β,17α,21-Trihydroxy-3,20-dioxo-pregnen-(4), sd. Eg., Zn-Acetat*2H2O, 2 h;

DOI:10.1021/ja01480a029

upstream raw materials:

HYDROCORTISONE