Technology Process of (R)-Procyclidine
There total 4 articles about (R)-Procyclidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ammonium fluoride / toluene; methanol / 0.5 h / 20 °C / Inert atmosphere
2: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 4 h / 40 °C
With
ammonium fluoride; 20% palladium hydroxide-activated charcoal; hydrogen;
In
methanol; toluene;
DOI:10.1021/jacs.9b01784
- Guidance literature:
-
Multi-step reaction with 3 steps
1: copper diacetate; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane / toluene / 12 h / 0 °C / Inert atmosphere
2: ammonium fluoride / toluene; methanol / 0.5 h / 20 °C / Inert atmosphere
3: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 4 h / 40 °C
With
ammonium fluoride; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; 20% palladium hydroxide-activated charcoal; hydrogen; copper diacetate;
In
methanol; toluene;
DOI:10.1021/jacs.9b01784
- Guidance literature:
-
Multi-step reaction with 3 steps
1: copper diacetate; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane / toluene / 12 h / 0 °C / Inert atmosphere
2: ammonium fluoride / toluene; methanol / 0.5 h / 20 °C / Inert atmosphere
3: 20% palladium hydroxide-activated charcoal; hydrogen / methanol / 4 h / 40 °C
With
ammonium fluoride; (+)-1,2-bis((2S,5S)-2,5-diphenylphospholanyl)ethane; 20% palladium hydroxide-activated charcoal; hydrogen; copper diacetate;
In
methanol; toluene;
DOI:10.1021/jacs.9b01784