94-39-3

Basic information

• Product Name: 1-PHENYL-3-(PYRROLIDIN-1-YL)PROPAN-1-ONE
• Synonyms: 1-PHENYL-3-(PYRROLIDIN-1-YL)PROPAN-1-ONE;1-Propanone,1-phenyl-3-(1-pyrrolidinyl)-;1-Phenyl-3-(1-pyrrolidinyl)-1-propanone;3-(1-Pyrrolidinyl)propiophenone
• CAS NO: 94-39-3
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28
• Mol File: 94-39-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 329℃
• Flash Point: 122℃
• Appearance: /
• Density: 1.051
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-PHENYL-3-(PYRROLIDIN-1-YL)PROPAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-3-(PYRROLIDIN-1-YL)PROPAN-1-ONE(94-39-3)
• EPA Substance Registry System: 1-PHENYL-3-(PYRROLIDIN-1-YL)PROPAN-1-ONE(94-39-3)

Safety Data

• Hazardous Substances Data: 94-39-3(Hazardous Substances Data)

Usage

General Description

1-PHENYL-3-(PYRROLIDIN-1-YL)PROPAN-1-ONE, also known as alpha-PVP, is a synthetic stimulant drug belonging to the cathinone class. It is a crystalline powder with stimulant and psychoactive effects similar to those of other synthetic cathinones. Alpha-PVP is known for its ability to produce feelings of euphoria, increased energy, and alertness. It is often used recreationally and is commonly found in products sold as "bath salts" or "research chemicals." The drug has been associated with adverse effects such as paranoia, hallucinations, and aggressive behavior, and its use has been linked to numerous hospitalizations and deaths. Alpha-PVP is considered a controlled substance in many countries due to its potential for abuse and harmful effects on health.

Upstream product

• 50-00-0 formaldehyd 
• 25150-61-2 pyrrolidine hydrochloride 
• 98-86-2 acetophenone 
• 52853-03-9 N-pyrrolidinylmethyleneimonium chloride 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 100-52-7 benzaldehyde 
• 123-75-1 pyrrolidine 
• 936-59-4 3-chloropropiophenone 
• 74-95-3 1,1-dibromomethane 
• 593-71-5 Chloroiodomethane 
• 75-09-2 dichloromethane 

Downstream Products

• 77-37-2 procyclidine 
• 77-64-5 1-(4-chloro-phenyl)-2-phenyl-4-pyrrolidino-butan-2-ol 
• 1384515-30-3 2-phenylhexahydro-2H-pyrrolo[2,1-b][1,3]oxazine 
• 4641-67-2 1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol 
• 37918-82-4 1-(3-phenylbut-3-en-1-yl)pyrrolidine 
• 136877-40-2 2-Hydroxy-1,2-diphenyl-4-pyrrolidin-1-yl-butane-1-sulfonic acid dimethylamide 
• 136877-37-7 1-(Morpholine-4-sulfonyl)-2-phenyl-4-pyrrolidin-1-yl-butan-2-ol 
• 136877-39-9 3-Hydroxy-3-phenyl-5-pyrrolidin-1-yl-pentane-2-sulfonic acid dimethylamide 
• 136877-30-0 2-Hydroxy-2-phenyl-4-pyrrolidin-1-yl-butane-1-sulfonic acid dimethylamide 
• 145880-05-3 4-((E)-1-Phenyl-3-pyrrolidin-1-yl-propenyl)-pyridine 
• 145880-07-5 4-((Z)-1-Phenyl-3-pyrrolidin-1-yl-propenyl)-pyridine 
• 145879-97-6 3-((E)-1-Phenyl-3-pyrrolidin-1-yl-propenyl)-pyridine 
• 145879-99-8 3-((Z)-1-Phenyl-3-pyrrolidin-1-yl-propenyl)-pyridine 
• 157846-79-2 1-[3-(3,4-Dimethoxy-phenoxy)-3-phenyl-propyl]-pyrrolidine 

Relevant articles and documents

Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.

Electrooxidative cyclization of hydroxyamino compounds possessing a benzyl group

Several novel 2-aryl-1,3-oxazinane and 2-aryl-1,3-oxazolidine derivatives were synthesized from N-benzyl-2-piperidineethanols and N-benzyl-2- piperidinemethanols, respectively, by using electrooxidative methods in methanol. For these reactions, the yields of the corresponding cyclized compounds were significantly increased by using catalytic amounts of iodide ions. In contrast, 3-dialkylamino-1-phenylpropanols afforded the expected cyclic 6-phenyl-1,3-oxazinane derivatives using only a small excess of base. Georg Thieme Verlag Stuttgart · New York.

Synthesis of 3-aryloxy-3-phenylpropanamines as possible antidepressants

Thirteen new 3-aryloxy-3-phenylpropanamines (11-23) have been prepared and their structures elucidated by mass, IR and 1H-NMR spectra and by elemental analysis.Being structurally similar to fluoxetine these compounds have been tested for their effect on g