(4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide

Base Information

Chemical Name:(4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide
CAS No.:129779-08-4
Molecular Formula:C₃₅H₅₅N₅O₆S
Molecular Weight:673.918
Hs Code.:

(4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide

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Chemical Property of (4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide

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Technology Process of (4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide

There total 9 articles about (4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15911-73-6
L-norleucine tert-butyl ester

: 129779-08-4,129831-76-1
(4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 1) KOH, 2) HOBT, DCC, NEt₃

2: 32 percent / NaBH₄ / ethanol / 6 h

3: pyridine

4: NaH / dimethylformamide / Ambient temperature

5: H₂O₂ / Na₂WO₄

6: 1) TFA, 2) NEt₃, DPPA / 1) CH₂Cl₂

With pyridine; potassium hydroxide; sodium tetrahydroborate; diphenyl-phosphinic acid; dihydrogen peroxide; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium tungstate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 2985-39-9,175521-78-5
2-benzylmalonic acid monoethyl ester

: 129779-08-4,129831-76-1
(4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 1) KOH, 2) HOBT, DCC, NEt₃

2: 32 percent / NaBH₄ / ethanol / 6 h

3: pyridine

4: NaH / dimethylformamide / Ambient temperature

5: H₂O₂ / Na₂WO₄

6: 1) TFA, 2) NEt₃, DPPA / 1) CH₂Cl₂

With pyridine; potassium hydroxide; sodium tetrahydroborate; diphenyl-phosphinic acid; dihydrogen peroxide; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium tungstate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 123802-80-2
(R)-2-hydroxymethyl-3-phenylpropionic acid

: 129779-08-4,129831-76-1
(4S,5S)-5-{(S)-2-[(S)-2-Benzyl-3-(pyrimidine-2-sulfonyl)-propionylamino]-hexanoylamino}-2-ethyl-4-hydroxy-7-methyl-octanoic acid isobutyl-amide

Guidance literature:: Multi-step reaction with 5 steps

1: HOBT, DCC

2: pyridine

3: NaH / dimethylformamide / Ambient temperature

4: H₂O₂ / Na₂WO₄

5: 1) TFA, 2) NEt₃, DPPA / 1) CH₂Cl₂

With pyridine; diphenyl-phosphinic acid; dihydrogen peroxide; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium tungstate; In N,N-dimethyl-formamide;