methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate

Base Information

Chemical Name:methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate
CAS No.:135246-04-7
Molecular Formula:C₂₄H₂₈N₂O₇
Molecular Weight:456.496
Hs Code.:

methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate

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Chemical Property of methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate

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Technology Process of methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate

There total 3 articles about methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 135246-03-6
8-benzyl-5-methyl (-)-(4aS,5R,7aR,9R,10aS)-2-benzyl-2,3,4,4a,5,6,7,7a,9,10-decahydro-1,7-dioxco-9-(hydroxymethyl)-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

: 107-21-1
ethylene glycol

: 135246-04-7
methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 24h; Heating;
DOI:10.1016/S0040-4020(01)96112-5

Reference yield:

: 128572-26-9
8-benzyl-5-methyl (-)-(4aS,5R,9R,10aS)-2-benzyl-9-<(tert-butyldiphenylsilyl)oxymethyl>-1-oxo-2,3,4,4a,5,6,9,10-octahydro-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

: 135246-04-7
methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1) OsO₄, pyridine, 2) p-toluenesulfonic acid monohydrate / 1) r.t., 16 h, 2) benzene, reflux, 30 min

2: 90 percent / TBAF / tetrahydrofuran / 1.5 h / Ambient temperature

3: 24 percent / p-toluenesulfonic acid monohydrate / toluene / 24 h / Heating

With pyridine; osmium(VIII) oxide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)96112-5

Reference yield:

: 135246-02-5
8-benzyl-5-methyl (+)-(4aS,5R,7aR,9R,10aS)-2-benzyl-9-<(tert-butyldiphenylsilyl)oxymethyl>-1,7-dioxo-2,3,4,4a,5,6,7a,9,10-nonahydro-pyrrolo<2,3-i>isoquinoline-5,8(1H)-dicarboxylate

: 135246-04-7
methyl (4aS,5R,7aR,10aR,11aS)-2-benzyl-2,3,4,4a,5,6,7,7a,7b,10,10a,11-dodecahydro-7,7-(ethylenedioxy)-1-oxo-oxazolo<3,4-j>pyrrolo<2,3-i>isoquinoline-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / TBAF / tetrahydrofuran / 1.5 h / Ambient temperature

2: 24 percent / p-toluenesulfonic acid monohydrate / toluene / 24 h / Heating

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)96112-5