Technology Process of (1S,2S)-1-(4-Fluoro-phenyl)-2-imidazol-1-yl-cycloheptanol
There total 3 articles about (1S,2S)-1-(4-Fluoro-phenyl)-2-imidazol-1-yl-cycloheptanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 35 percent / ethanol / 70 h / Heating
2: 1.) trifluoroacetic anhydride, dimethyl sulfoxide, 2.) triethylamine / 1.) CH2Cl2, room temperature, 2 h, 2.) from -65 deg C to 0 deg C, 1 h
3: 58 percent / tetrahydrofuran / 1 h / Ambient temperature
With
dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran; ethanol;
DOI:10.3987/COM-89-5280
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) trifluoroacetic anhydride, dimethyl sulfoxide, 2.) triethylamine / 1.) CH2Cl2, room temperature, 2 h, 2.) from -65 deg C to 0 deg C, 1 h
2: 58 percent / tetrahydrofuran / 1 h / Ambient temperature
With
dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride;
In
tetrahydrofuran;
DOI:10.3987/COM-89-5280
