4--3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine

Base Information

Chemical Name:4--3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine
CAS No.:75288-34-5
Molecular Formula:C₂₂H₁₃ClN₂O₅
Molecular Weight:420.809
Hs Code.:

4-<trans-1-(4-chlorophenyl)-1-oxoprop-2-en-3-yl>-3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4--3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine

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Technology Process of 4--3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine

There total 3 articles about 4--3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 75288-21-0
2-bromo-2-(4-nitrophenyl)acetyl chloride

: 74793-93-4
1--3-hydroxypyrimidinium chloride

: 75288-34-5
4--3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine

Guidance literature:: With triethylamine; In dichloromethane; 1.) 0 deg C, 15 min, 2.) room temperature, 2 h;
DOI:10.1039/P19800001176

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 75288-34-5
4--3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CCl₄ / 65 °C

2: N-bromosuccinimide, conc. HBr / CCl₄ / 4 h / 85 °C

3: 83 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 2 h

With N-Bromosuccinimide; thionyl chloride; hydrogen bromide; triethylamine; In tetrachloromethane; dichloromethane;
DOI:10.1039/P19800001176

Reference yield:

: 50434-36-1
4-nitrophenylacetyl chloride

: 75288-34-5
4--3-(4-nitrophenyl)-2-oxo-2,4-dihydrofuro<3,2-b>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: N-bromosuccinimide, conc. HBr / CCl₄ / 4 h / 85 °C

2: 83 percent / Et₃N / CH₂Cl₂ / 1.) 0 deg C, 15 min, 2.) room temperature, 2 h

With N-Bromosuccinimide; hydrogen bromide; triethylamine; In tetrachloromethane; dichloromethane;
DOI:10.1039/P19800001176