<(2R,4aR,5aR,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetat

Base Information

• Chemical Name: <(2R,4aR,5aR,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetat
• CAS No.: 131570-07-5
• Molecular Formula: C₂₂H₂₀O₇
• Molecular Weight: 396.397
• Mol file: 131570-07-5.mol

Synonyms:

Chemical Property of <(2R,4aR,5aR,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <(2R,4aR,5aR,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetat

There total 4 articles about <(2R,4aR,5aR,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

Acetic acid (2R,4aR,5aS,6R,11aR,12R,12aR)-6-hydroxy-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester (131570-05-3,131615-93-5,131615-94-6) → <(2R,4aR,5aR,6R,11aR,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetate (131570-07-5,131615-97-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1002/hlca.19900730715

Reference yield: 41.0%

Acetic acid (2R,4aR,5aS,6R,11aS,12R,12aR)-6-hydroxy-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester (131570-05-3,131615-93-5,131615-94-6) → <(2R,4aR,5aR,11aS,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetat (131570-07-5,131615-97-9)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; Ambient temperature;

DOI:10.1002/hlca.19900730715

Reference yield:

Acetic acid (2R,4aR,5aS,11aS,12S,12aR)-6-hydroxy-5a-nitro-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester (131570-02-0,131615-91-3) → <(2R,4aR,5aR,6R,11aR,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-6-oxo-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-12-yl>-acetate (131570-07-5,131615-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Bu3SnH, α,α'-azoisobutyronitrile / benzene / 4 h / Heating

2: 54 percent / MnO₂ / CH₂Cl₂ / 16 h / Ambient temperature

With manganese(IV) oxide; azobisisobutyronitrile; tri-n-butyl-tin hydride; In dichloromethane; benzene;

DOI:10.1002/hlca.19900730715

upstream raw materials:

Acetic acid (2R,4aR,5aS,6R,11aR,12R,12aR)-6-hydroxy-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester

Acetic acid (2R,4aR,5aS,11aS,12S,12aR)-6-hydroxy-5a-nitro-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester

Acetic acid (2R,4aR,5aS,6R,11aS,12R,12aR)-6-hydroxy-2-phenyl-4a,5a,6,11a,12,12a-hexahydro-4H-1,3,5,11-tetraoxa-naphthacen-12-yl ester

Downstream raw materials:

<(2R,4aR,5aR,6S,11aR,12R,12aR)-4a,5a,6,11a,12,12a-hexahydro-2-phenyl-2H,4H-<1,3>dioxino<4',5':5,6>pyrano<3,2-b><1>benzopyran-6,12-diyl>diacetat