Malonic acid (E)-1,3-diphenyl-allyl ester ethyl ester

Base Information

• Chemical Name: Malonic acid (E)-1,3-diphenyl-allyl ester ethyl ester
• CAS No.: 297162-65-3
• Molecular Formula: C₂₀H₂₀O₄
• Molecular Weight: 324.376
• Mol file: 297162-65-3.mol

Synonyms:

Chemical Property of Malonic acid (E)-1,3-diphenyl-allyl ester ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Malonic acid (E)-1,3-diphenyl-allyl ester ethyl ester

There total 2 articles about Malonic acid (E)-1,3-diphenyl-allyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogen ethyl malonate (1071-46-1) + (E)-1,3-diphenyl-2-propen-1-ol (62668-02-4) → Malonic acid (E)-1,3-diphenyl-allyl ester ethyl ester (297162-65-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In diethyl ether; at 0 - 20 ℃; for 5h;

DOI:10.1016/S0040-4020(98)01109-0

Reference yield:

iodobenzene (591-50-4) → Malonic acid (E)-1,3-diphenyl-allyl ester ethyl ester (297162-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg / 1.) Et₂O, 2.) Et₂O, reflux

2: dicyclohexyl-carbodiimide / diethyl ether / 5 h / 0 - 20 °C

With magnesium; dicyclohexyl-carbodiimide; In diethyl ether;

DOI:10.1016/S0040-4020(98)01109-0

Reference yield:

Malonic acid (E)-1,3-diphenyl-allyl ester ethyl ester (297162-65-3) → (1R,4S,5S,6S)-2-Oxo-4,6-diphenyl-3-oxa-bicyclo[3.1.0]hexane-1-carboxylic acid ethyl ester + ethyl r-1,2-oxo-cis-4,cis-6-Diphenyl-3-oxabicyclo[3.1.0]hexane-1-carboxylate

Guidance literature:

With iodine; potassium carbonate; In toluene; at 110 ℃; for 3h; Yield given; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(98)01109-0

upstream raw materials:

hydrogen ethyl malonate

(E)-1,3-diphenyl-2-propen-1-ol

iodobenzene