(+)-Loline dihydrochloride

Base Information

Chemical Name:(+)-Loline dihydrochloride
CAS No.:25161-92-6
Molecular Formula:C₈H₁₄N₂O*2ClH
Molecular Weight:227.134
Hs Code.:

Synonyms:

Suppliers and Price of (+)-Loline dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(+)-LolineDihydrochloride
5mg
$ 4290.00

Medical Isotopes, Inc.
(+)-LolineDiHCl
0.25 mg
$ 825.00

Total 2 raw suppliers

Chemical Property of (+)-Loline dihydrochloride

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

(+)-LolineDihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (+)-Loline Dihydrochloride is an alkaloid isolated from fungal endophytes, an endosymbiont that lives within a plant. Loline alkaloids were found to provide protection of host plants from aphids herbivory and environmental stresses such as drought and spatial competition.

Technology Process of (+)-Loline dihydrochloride

There total 7 articles about (+)-Loline dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25161-91-5,103616-00-8,30484-80-1
(+)-Loline

: 25161-92-6,92469-90-4
(+)-Loline dihydrochloride

Guidance literature:: With hydrogenchloride; In methanol; Inert atmosphere;
DOI:10.1038/nchem.1072

Reference yield:

: C₁₅H₁₇NO₅S

: 25161-92-6,92469-90-4
(+)-Loline dihydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: lithium azide; water / N,N-dimethyl-formamide / 2.5 h / 130 °C / Inert atmosphere

2: bromine / 0 h / 12 °C / Inert atmosphere; Darkness

3: lithium chloride / N,N-dimethyl-formamide / 6 h / 105 °C / Inert atmosphere

4: potassium carbonate / methanol / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

5: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

6: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

7: hydrogenchloride / methanol / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; lithium azide; palladium 10% on activated carbon; water; hydrogen; bromine; potassium carbonate; lithium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1038/nchem.1072

Reference yield:

: C₁₅H₁₈N₄O₃

: 25161-92-6,92469-90-4
(+)-Loline dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: bromine / 0 h / 12 °C / Inert atmosphere; Darkness

2: lithium chloride / N,N-dimethyl-formamide / 6 h / 105 °C / Inert atmosphere

3: potassium carbonate / methanol / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere

5: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

6: hydrogenchloride / methanol / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; bromine; potassium carbonate; lithium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1038/nchem.1072