2,4-Methano-4H-furo(3,2-b)pyrrole, hexahydro-3-(methylamino)-

Base Information Edit

Chemical Name:2,4-Methano-4H-furo(3,2-b)pyrrole, hexahydro-3-(methylamino)-
CAS No.:25161-91-5
Molecular Formula:C₈H₁₄N₂O
Molecular Weight:154.212
Hs Code.:
DSSTox Substance ID:DTXSID30948022
Mol file:25161-91-5.mol

Synonyms:DTXSID30948022;N-methylhexahydro-1H-1,6-epoxypyrrolizin-7-amine

Suppliers and Price of 2,4-Methano-4H-furo(3,2-b)pyrrole, hexahydro-3-(methylamino)-

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Arctom
Loline
5mg
$ 418.00

American Custom Chemicals Corporation
LOLINE 95.00%
5MG
$ 499.38

Total 5 raw suppliers

Chemical Property of 2,4-Methano-4H-furo(3,2-b)pyrrole, hexahydro-3-(methylamino)- Edit

Chemical Property:

Boiling Point:232.6°Cat760mmHg
PKA:9.36±0.20(Predicted)
Flash Point:94.5°C
PSA：24.50000
Density:1.2g/cm³
LogP:-0.24150
XLogP3:-0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:154.110613074
Heavy Atom Count:11
Complexity:185

Purity/Quality:

99% ^*data from raw suppliers

Loline ^*data from reagent suppliers

Safty Information:

Pictogram(s): A poison.
Hazard Codes:A poison.

MSDS Files:

Useful:

Canonical SMILES:CNC1C2CN3C1C(O2)CC3
Isomeric SMILES:CN[C@H]1[C@H]2CN3[C@@H]1C(O2)CC3
Description This oily alkaloid has been obtained from a species of grass, Lotium cuneatum Nevski. It has a density of D 20 1.1343 and a refractive index of n20D 1.5505. It behaves as a diacidic base yielding a series of well crystalline salts and derivatives, e.g. the dihydrochloride, m.p. 256-7°C; [α]15D + 6.2° (H20); dihydrobromide, m.p. 254-5°C (dec.); [α]20D + 3.5° (c 4.29, H20); dihydriodide, m.p. 233-5°C (dec.); [α]34D + 5.0° (c 13.2 H20); perchlorate, m.p. 282°C with almost explosive decomposition; sulphate, yellow needles, m.p. 250-2°C (dec.); mononitrate,m.p. 208-2l0°C; dinitrate, m.p. l48-9°C; [α]38D + 6.18° (c 6.94, H20); dipicrate, m.p. 258-260°C (dec.); methiodide, m.p. 2l0-loC and the N-nitroso derivative, m.p. 64°C. The N-acetyl derivative yields a crystalline hydrochloride, m.p. 197-8°C; [α]20D + 36.9° (H20) and the N-methyl compound is obtained as a colourless oil, b.p. 90-l oC/2 mm; [α]31D+ 9.31° (c 9.5, MeOH). The alkaloid possesses an ether oxygen bridging the pyrrolizidine moiety.

Technology Process of 2,4-Methano-4H-furo(3,2-b)pyrrole, hexahydro-3-(methylamino)-

There total 15 articles about 2,4-Methano-4H-furo(3,2-b)pyrrole, hexahydro-3-(methylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 290836-00-9
N-Tosylloline

: 25161-91-5,103616-00-8,30484-80-1
(+)-Loline

Guidance literature:: With sodium naphthalenide; In 1,2-dimethoxyethane; at -60 ℃; for 0.333333h;

Reference yield:

: 290835-99-3
{(1R,2S,7S,7aS)-7-hydroxy-1-[methyl(4-tolylsulfonyl)amino]hexahydro-1H-pyrrolizin-2-yl} methanesulfonate

: 25161-91-5,103616-00-8,30484-80-1
(+)-Loline

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / 1,2-dichloro-benzene / 22 h / 180 °C

2: sodium naphthalenide / 1,2-dimethoxy-ethane / 0.33 h / -60 °C

With sodium naphthalenide; In 1,2-dimethoxyethane; 1,2-dichloro-benzene;

Reference yield:

: 290835-96-0
N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide

: 25161-91-5,103616-00-8,30484-80-1
(+)-Loline

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2: BH₃*SMe₂ / tetrahydrofuran / 5 h / 20 °C

3: 15.0 mg / Pd(OH)2/C / methanol / 14 h / 20 °C

4: 70 percent / DDQ; H₂O / CH₂Cl₂ / 64 h / 20 °C

5: 74 percent / 1,2-dichloro-benzene / 22 h / 180 °C

6: sodium naphthalenide / 1,2-dimethoxy-ethane / 0.33 h / -60 °C

With dimethylsulfide borane complex; water; sodium naphthalenide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-benzene;