(R)-(-)-1-cyclohexyl-1,2-ethylene glycol

Base Information

• Chemical Name: (R)-(-)-1-cyclohexyl-1,2-ethylene glycol
• CAS No.: 125874-67-1
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.214
• Mol file: 125874-67-1.mol

Synonyms:

Chemical Property of (R)-(-)-1-cyclohexyl-1,2-ethylene glycol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-1-cyclohexyl-1,2-ethylene glycol

There total 40 articles about (R)-(-)-1-cyclohexyl-1,2-ethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

vinylcyclohexane (695-12-5,25498-06-0) → 1-cyclohexylethane-1,2-diol (61414-09-3,87858-06-8,125874-67-1,59411-58-4)

Guidance literature:

With 4-methylmorpholine N-oxide; In water; acetone; at 20 ℃; for 3.5h; Inert atmosphere;

DOI:10.1055/s-0034-1379990

Reference yield: 96.0%

vinylcyclohexane (695-12-5,25498-06-0) → (R)-1-cyclohexylethane-1,2-diol (59411-58-4,61414-09-3,125874-67-1,87858-06-8)

Guidance literature:

With methanesulfonamide; AD-mix β; water; In ethanol; at 4 ℃; for 24h;

DOI:10.1002/chir.23223

Reference yield: 91.0%

cyclohexyl-oxo-acetic acid methyl ester (62783-63-5) → 1-cyclohexylethane-1,2-diol (61414-09-3,87858-06-8,125874-67-1,59411-58-4)

Guidance literature:

With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium t-butanolate; In methanol; at 80 ℃; for 12h; under 37503.8 Torr; chemoselective reaction; Glovebox; Autoclave;

DOI:10.1055/s-0035-1561971

upstream raw materials:

1-cyclohexyl-2-hydroxyethanone

(1,2-diacetoxyethyl)cyclohexane

vinylcyclohexane

Cyclohexyloxirane

Downstream raw materials:

1-cyclohexyl-2-hydroxyethanone

(2R,4R)-4-Cyclohexyl-2-phenyl-[1,3]dioxolane

4-cyclohexyl-2-phenyl-1,3-dioxolane

(S)-2-cyclohexyloxirane