methyl 2-cyclohexyl-2-oxoacetate

Base Information

• Chemical Name: methyl 2-cyclohexyl-2-oxoacetate
• CAS No.: 62783-63-5
• Molecular Formula: C9H14O3
• Molecular Weight: 170.208
• Hs Code.: 2918300090
• Mol file: 62783-63-5.mol

Synonyms:Methyl 2-cyclohexyl-2-oxoacetate;methyl cyclohexylglyoxylate;Methyl-hexahydrobenzoylformiat;

Chemical Property of methyl 2-cyclohexyl-2-oxoacetate

Chemical Property:

• PSA: 43.37000
• LogP: 1.30880
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-cyclohexyl-2-oxoacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-cyclohexyl-2-oxoacetate

There total 5 articles about methyl 2-cyclohexyl-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

rac-methyl 2-cyclohexyl-2-hydroxyacetate (99183-16-1) → cyclohexyl-oxo-acetic acid methyl ester (62783-63-5)

Guidance literature:

With oxygen; vanadium(V) oxychloride; In acetonitrile; at 20 ℃;

DOI:10.1039/a903622i

Reference yield: 90.0%

methanol (67-56-1) + 1-chloro-2-cyclohexylethyne (50284-86-1) → cyclohexyl-oxo-acetic acid methyl ester (62783-63-5)

Guidance literature:

With potassium permanganate; sodium hydrogencarbonate; magnesium sulfate; In water; at 0 - 20 ℃; for 2h;

Reference yield: 75.0%

monomethyl oxalyl chloride (5781-53-3) + cyclohexylmagnesium bromide (931-50-0) → cyclohexyl-oxo-acetic acid methyl ester (62783-63-5)

Guidance literature:

With copper(I) bromide; lithium bromide; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1016/0040-4020(96)00805-8

upstream raw materials:

monomethyl oxalyl chloride

cyclohexylmagnesium bromide

rac-methyl 2-cyclohexyl-2-hydroxyacetate

methanol

Downstream raw materials:

Methyl (S)-α-hydroxycyclohexaneacetate

Methyl (R)-α-hydroxycyclohexaneacetate

1-cyclohexyl-3-phenylpropane-1,3-dione

1-cyclohexylethane-1,2-diol

Refernces

• 1、 -. "PIPECOLATE-DIKETOAMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS". Page/Page column 36. . Retrieved 2013/07/05.
• 2、 -. "Bicyclic heterocycles as cannabinoind-1 receptor modulators". Page/Page column 17. . Retrieved 2008/06/13.