(-)-1,2-diacetoxyherbertene

Base Information

• Chemical Name: (-)-1,2-diacetoxyherbertene
• CAS No.: 103412-30-2
• Molecular Formula: C₁₉H₂₆O₄
• Molecular Weight: 318.413
• Mol file: 103412-30-2.mol

Synonyms:

Chemical Property of (-)-1,2-diacetoxyherbertene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-1,2-diacetoxyherbertene

There total 8 articles about (-)-1,2-diacetoxyherbertene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,14-dihydroxyherbertene (86996-96-5) → (-)-1,2-diacetoxyherbertene (103412-30-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) triphenyl phosphite methiodide, 2.) 5percent aqeous sodium tiosulphate / 1.) HMPA, 3.5 h, room temperature

2: 17 mg / AlCl₃ / 6 h / ice-bath

3: 12 percent / W-4 Raney nickel / ethanol / 1.5 h / Heating

4: 1.) benzoyl peroxide, 2.) LiAlH₄ / 1.) benzene, 90-100 deg C, 1 h, 2.) ether, ice-bath, 3 h

5: 32 mg / pyridine / 3 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; Perbenzoic acid; triphenyl phosphite methiodide; sodium thiosulfate; W-4 Raney nickel; In ethanol;

Reference yield:

(-)-herbertenolide (86996-94-3) → (-)-1,2-diacetoxyherbertene (103412-30-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 23 mg / LiAlH₄ / diethyl ether / 2 h / ice-bath

2: 1.) triphenyl phosphite methiodide, 2.) 5percent aqeous sodium tiosulphate / 1.) HMPA, 3.5 h, room temperature

3: 17 mg / AlCl₃ / 6 h / ice-bath

4: 12 percent / W-4 Raney nickel / ethanol / 1.5 h / Heating

5: 1.) benzoyl peroxide, 2.) LiAlH₄ / 1.) benzene, 90-100 deg C, 1 h, 2.) ether, ice-bath, 3 h

6: 32 mg / pyridine / 3 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; Perbenzoic acid; triphenyl phosphite methiodide; sodium thiosulfate; W-4 Raney nickel; In diethyl ether; ethanol;

Reference yield:

1,14-epoxyherbertene (87016-04-4) → (-)-1,2-diacetoxyherbertene (103412-30-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 17 mg / AlCl₃ / 6 h / ice-bath

2: 12 percent / W-4 Raney nickel / ethanol / 1.5 h / Heating

3: 1.) benzoyl peroxide, 2.) LiAlH₄ / 1.) benzene, 90-100 deg C, 1 h, 2.) ether, ice-bath, 3 h

4: 32 mg / pyridine / 3 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; Perbenzoic acid; W-4 Raney nickel; In ethanol;

upstream raw materials:

acetic anhydride

(S)-5-methyl-3-(1,2,2-trimethylcyclopentyl)benzene-1,2-diol

4-methyl-2-[(1S)-1,2,2-trimethylcyclopentyl]phenol

1,14-epoxyherbertene