(1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid

Base Information

Chemical Name:(1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid
CAS No.:80299-99-6
Molecular Formula:C₇H₈O₃S*C₁₂H₁₅N₅O₃
Molecular Weight:449.488
Hs Code.:

(1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid

Synonyms:

Suppliers and Price of (1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid

There total 8 articles about (1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 80299-99-6
(1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 10 g / potassium carbonate / dimethylformamide / 20 h / Ambient temperature

2: chlorine / CCl₄ / 1.5 h / -20 - 0 °C

3: 6.11 g / sodium azide / dimethylformamide / 18 h / Ambient temperature

4: 350 mg / litium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -76 °C

5: 86 percent / toluene / 8 h / Heating

6: 448 mg / lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.33 h / -76 °C

7: 265 mg / m-chloroperbenzoic acid / ethyl acetate / 0 °C

8: CH₂Cl₂; methanol / 2.5 h / 5 °C

With sodium azide; chlorine; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1039/P19810002544

Reference yield:

: [(R)-2-Chloro-4-oxo-3-(trityl-amino)-azetidin-1-yl]-acetic acid tert-butyl ester

: 80299-99-6
(1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 6.11 g / sodium azide / dimethylformamide / 18 h / Ambient temperature

2: 350 mg / litium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -76 °C

3: 86 percent / toluene / 8 h / Heating

4: 448 mg / lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.33 h / -76 °C

5: 265 mg / m-chloroperbenzoic acid / ethyl acetate / 0 °C

6: CH₂Cl₂; methanol / 2.5 h / 5 °C

With sodium azide; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1039/P19810002544

Reference yield:

: 72819-38-6
t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate

: 80299-99-6
(1S,7bR)-1-Amino-2-oxo-1,7b-dihydro-2H-2a,6,7,7a-tetraaza-cyclobuta[e]indene-3-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid

Guidance literature:: Multi-step reaction with 7 steps

1: chlorine / CCl₄ / 1.5 h / -20 - 0 °C

2: 6.11 g / sodium azide / dimethylformamide / 18 h / Ambient temperature

3: 350 mg / litium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -76 °C

4: 86 percent / toluene / 8 h / Heating

5: 448 mg / lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.33 h / -76 °C

6: 265 mg / m-chloroperbenzoic acid / ethyl acetate / 0 °C

7: CH₂Cl₂; methanol / 2.5 h / 5 °C

With sodium azide; chlorine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; tetrachloromethane; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1039/P19810002544