Technology Process of phenacyl-3 p-tolyl-2 dihydro-2,3 (4H) pyrido<3,2-e> thiazine-1,3 one-4
There total 5 articles about phenacyl-3 p-tolyl-2 dihydro-2,3 (4H) pyrido<3,2-e> thiazine-1,3 one-4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: H2S, Dowex 50W-X8 / methanol / 1.) -30 deg C, 15 min, 2.) -20 deg C, 1 h,
2: 1.) NaH / 1.) NMP, 0 deg C, 15 min, 2.) NMP, 140 deg C, 1 h,
3: 81 percent / NaBH4 / ethanol / 0.5 h / Heating
4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 50 deg C, 90 min,
With
sodium tetrahydroborate; Dowex 50W-X8; hydrogen sulfide; sodium hydride;
In
methanol; ethanol;
DOI:10.1016/S0040-4020(01)81311-9
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) NMP, 0 deg C, 15 min, 2.) NMP, 140 deg C, 1 h,
2: 81 percent / NaBH4 / ethanol / 0.5 h / Heating
3: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 50 deg C, 90 min,
With
sodium tetrahydroborate; sodium hydride;
In
ethanol;
DOI:10.1016/S0040-4020(01)81311-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 81 percent / NaBH4 / ethanol / 0.5 h / Heating
2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, 50 deg C, 90 min,
With
sodium tetrahydroborate; sodium hydride;
In
ethanol;
DOI:10.1016/S0040-4020(01)81311-9
