4-methyl-2-(1,3-pentadecadienyl)-1-tosylazetidine

Base Information

• Chemical Name: 4-methyl-2-(1,3-pentadecadienyl)-1-tosylazetidine
• CAS No.: 97478-26-7
• Molecular Formula: C₂₆H₄₁NO₂S
• Molecular Weight: 431.683
• Mol file: 97478-26-7.mol

Synonyms:

Chemical Property of 4-methyl-2-(1,3-pentadecadienyl)-1-tosylazetidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-2-(1,3-pentadecadienyl)-1-tosylazetidine

There total 6 articles about 4-methyl-2-(1,3-pentadecadienyl)-1-tosylazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-methyl-2-(1,3-pentadecadienyl)-1-tosylazetidine (97478-26-7,97478-27-8,124994-19-0,124994-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) H₂, 2.) pyridine / 1.) 10percent palladium on charcoal / 1.) methanol, room temp., 1 atm, 22 h, 2.) 0 deg C, then room temp., 2 h

2: diisobutylaluminum hydride / hexane; CH₂Cl₂ / 0.25 h / -78 °C

3: 1.) potassium t-butoxide / 1.) diethyl ether, 0 deg C, 10 min., 2.) room temp., 1 h

With pyridine; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In hexane; dichloromethane;

DOI:10.1016/S0040-4020(01)80135-6

Reference yield:

methyl α,γ-dibromovalerate (33667-63-9) → 4-methyl-2-(1,3-pentadecadienyl)-1-tosylazetidine (97478-26-7,97478-27-8,124994-19-0,124994-20-3)

Guidance literature:

Multi-step reaction with 4 steps

1: acetonitrile / 1.5 h / 60 °C

2: 1.) H₂, 2.) pyridine / 1.) 10percent palladium on charcoal / 1.) methanol, room temp., 1 atm, 22 h, 2.) 0 deg C, then room temp., 2 h

3: diisobutylaluminum hydride / hexane; CH₂Cl₂ / 0.25 h / -78 °C

4: 1.) potassium t-butoxide / 1.) diethyl ether, 0 deg C, 10 min., 2.) room temp., 1 h

With pyridine; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In hexane; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(01)80135-6

Reference yield:

(Z,E) 1-benzyl-2-carbobenzyloxy-4-methylazetidine (97478-50-7) → 4-methyl-2-(1,3-pentadecadienyl)-1-tosylazetidine (97478-26-7,97478-27-8,124994-19-0,124994-20-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) H₂, 2.) pyridine / 1.) 10percent palladium on charcoal / 1.) methanol, room temp., 1 atm, 22 h, 2.) 0 deg C, then room temp., 2 h

2: diisobutylaluminum hydride / hexane; CH₂Cl₂ / 0.25 h / -78 °C

3: 1.) potassium t-butoxide / 1.) diethyl ether, 0 deg C, 10 min., 2.) room temp., 1 h

With pyridine; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In hexane; dichloromethane;

DOI:10.1016/S0040-4020(01)80135-6

upstream raw materials:

4-Methyl-1-(toluene-4-sulfonyl)-azetidine-2-carbaldehyde

Triphenyl-((E)-tetradec-2-enylidene)-λ⁵-phosphane

methyl α,γ-dibromovalerate

4-Methyl-1-(toluene-4-sulfonyl)-azetidine-2-carboxylic acid methyl ester

Downstream raw materials:

6-Isopropenyl-2-methyl-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine

6-methyl-2-(1-tridecenyl)-1-tosyl-3,4-dehydropiperidine