(R)-N-(2-trifluoromethylbenzylbenzyl)-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Base Information

• Chemical Name: (R)-N-(2-trifluoromethylbenzylbenzyl)-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
• CAS No.: 226998-07-8
• Molecular Formula: C₂₄H₂₈F₃N₃O₃S
• Molecular Weight: 495.566
• Mol file: 226998-07-8.mol

Synonyms:

Chemical Property of (R)-N-(2-trifluoromethylbenzylbenzyl)-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(2-trifluoromethylbenzylbenzyl)-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

There total 6 articles about (R)-N-(2-trifluoromethylbenzylbenzyl)-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(1S,2S)-1-Benzyl-3-[(R)-5,5-dimethyl-4-(2-trifluoromethyl-benzylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid tert-butyl ester → (R)-N-(2-trifluoromethylbenzylbenzyl)-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (226998-07-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 3h; Yield given;

DOI:10.1021/jm980637h

Reference yield:

L-penicillamine (1113-41-3) → (R)-N-(2-trifluoromethylbenzylbenzyl)-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (226998-07-8)

Guidance literature:

Multi-step reaction with 6 steps

1: H₂O

2: aq. NaOH / tetrahydrofuran

3: 1.) Et₃N, DPP-Cl, 2.) Et₃N / 1.) EtOAc, 0 deg C, 1 h, 2.) EtOAc, overnight

4: 4 N HCl / dioxane / 2 h

5: HOBt, EDC*HCl / dimethylformamide

6: 4 N HCl / CH₂Cl₂; dioxane / 3 h

With hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; Diphenylphosphinic chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm980637h

Reference yield:

(R)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid (117918-23-7) → (R)-N-(2-trifluoromethylbenzylbenzyl)-3-<(2S,3S)-3-amino-2-hydroxy-4-phenylbutanoyl>-5,5-dimethyl-1,3-thiazolidine-4-carboxamide (226998-07-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Et₃N, DPP-Cl, 2.) Et₃N / 1.) EtOAc, 0 deg C, 1 h, 2.) EtOAc, overnight

2: 4 N HCl / dioxane / 2 h

3: HOBt, EDC*HCl / dimethylformamide

4: 4 N HCl / CH₂Cl₂; dioxane / 3 h

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; Diphenylphosphinic chloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980637h

upstream raw materials:

L-penicillamine

(R)-3-tert-butoxycarbonyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

(R)-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid

(R)-N-(2-trifluoromethylbenzyl)-5,5-dimethyl-1,3-thiazolidine-4-carboxamide

Downstream raw materials:

Acetic acid 3-{(1S,2S)-1-benzyl-3-[(R)-5,5-dimethyl-4-(2-trifluoromethyl-benzylcarbamoyl)-thiazolidin-3-yl]-2-hydroxy-3-oxo-propylcarbamoyl}-2-methyl-phenyl ester