5'-O-<(4-Methoxyphenyl)diphenylmethyl>thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin-(2-cyanethyl)ester

Base Information

• Chemical Name: 5'-O-<(4-Methoxyphenyl)diphenylmethyl>thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin-(2-cyanethyl)ester
• CAS No.: 60170-35-6
• Molecular Formula: C₅₆H₅₂N₇O₁₃P
• Molecular Weight: 1062.04
• Mol file: 60170-35-6.mol

Synonyms:

Chemical Property of 5'-O-<(4-Methoxyphenyl)diphenylmethyl>thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin-(2-cyanethyl)ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-<(4-Methoxyphenyl)diphenylmethyl>thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin-(2-cyanethyl)ester

There total 3 articles about 5'-O-<(4-Methoxyphenyl)diphenylmethyl>thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin-(2-cyanethyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

JUBVOR (35777-74-3) + Triethylammonium-<2-cyanethyl><5'-O-<(4-methoxyphenyl)diphenylmethyl>thymidin-3'>phosphat (73577-60-3) → 5'-O-<(4-Methoxyphenyl)diphenylmethyl>thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin-(2-cyanethyl)ester (60170-35-6)

Guidance literature:

With TPS; In pyridine; for 90h; Ambient temperature;

Reference yield: 44.0%

JUBVOR (35777-74-3) + Pyridinium-<2-cyanethyl><5'-O-<(4-methoxyphenyl)diphenylmethyl>thymidin-3'>phosphat (73577-73-8) → 5'-O-<(4-Methoxyphenyl)diphenylmethyl>thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin-(2-cyanethyl)ester (60170-35-6)

Guidance literature:

With TPS; In pyridine; Ambient temperature; 2-3 d;

Reference yield:

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine (42926-80-7) → 5'-O-<(4-Methoxyphenyl)diphenylmethyl>thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin-(2-cyanethyl)ester (60170-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Ambient temperature; 14-18 h

2: 44 percent / TPS / pyridine / Ambient temperature; 2-3 d

With TPS; In pyridine;

upstream raw materials:

JUBVOR

Triethylammonium-<2-cyanethyl><5'-O-<(4-methoxyphenyl)diphenylmethyl>thymidin-3'>phosphat

Pyridinium-<2-cyanethyl><5'-O-<(4-methoxyphenyl)diphenylmethyl>thymidin-3'>phosphat

5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

Downstream raw materials:

Ammonium-thymidylyl(3'-5')-1-(2'-desoxy-β-D-ribofuranosyl)-6,7-diphenyllumazin

C₃₆H₃₆N₇O₁₂P